Login   |   Register
Cover Image


Taxane-induced morphea in a patient with CREST syndrome

Susan Michele Bouchard, Melinda Mohr, Robert Pariser

Authors information
  • Melinda Mohr
    Eastern Virginia Medical School, Department of Dermatology, United States.
  • Robert Pariser
    Eastern Virginia Medical School, Department of Dermatology, United States.

Abstract


The taxanes, docetaxel and paclitaxel, are microtubule stabilizing chemotherapeutic agents that have demonstrated antineoplastic effects in a variety of solid tumors. They have been linked to the development of localized cutaneous sclerosis in some patients. We present a case of docetaxel-induced cutaneous sclerosis of the lower extremities in a patient with pre-existing CREST syndrome. We propose that patients with a history of limited or diffuse systemic sclerosis should be given taxane chemotherapy with caution, as these patients may have an immunological predisposition for the development of drug-induced morphea.

Keywords


CREST syndrome; scleroderma; morphea; docetaxel; taxane

Full Text





Submitted: 2010-06-29 21:32:13
Published: 2010-07-20 08:42:49
Search for citations in Google Scholar
Related articles: Google Scholar


Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

 

Dermatology Reports [eISSN 2036-7406] is an Open Access, peer-reviewed journal published by PAGEPress, Pavia, Italy. All credits and honors to PKP for their OJS.

 

 

 
 
© PAGEPress 2008-2014     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185