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Taxane-induced morphea in a patient with CREST syndrome

Susan Michele Bouchard, Melinda Mohr, Robert Pariser
  • Melinda Mohr
    Eastern Virginia Medical School, Department of Dermatology, United States
  • Robert Pariser
    Eastern Virginia Medical School, Department of Dermatology, United States


The taxanes, docetaxel and paclitaxel, are microtubule stabilizing chemotherapeutic agents that have demonstrated antineoplastic effects in a variety of solid tumors. They have been linked to the development of localized cutaneous sclerosis in some patients. We present a case of docetaxel-induced cutaneous sclerosis of the lower extremities in a patient with pre-existing CREST syndrome. We propose that patients with a history of limited or diffuse systemic sclerosis should be given taxane chemotherapy with caution, as these patients may have an immunological predisposition for the development of drug-induced morphea.


CREST syndrome; scleroderma; morphea; docetaxel; taxane

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Submitted: 2010-06-29 21:32:13
Published: 2010-07-20 08:42:49
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