Bullous mycosis fungoides associated with an extensive ulcer and a severe leukemoid reaction


https://doi.org/10.4081/dr.2011.e54
Vol. 3 No. 3 (2011)
Submitted: 17 March 2011
Accepted: 18 November 2011
Published: 2 December 2011
bullous mycosis fungoides, leukemoid reaction, pseudomembranous colitis.
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Authors

  • Shuei Sato Department of Dematology, Faculty of medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, Japan.
  • Osamu Okamoto
    ookamoto@oita-u.ac.jp
    Department of Dematology, Faculty of medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, Japan.
  • Michifumi Kawamoto Department of Dematology, Faculty of medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, Japan.
  • Masaki Oishi Department of Dematology, Faculty of medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, Japan.
  • Naomi Yada Department of Pathology, Faculty of medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, Japan.
  • Kazuhiro Kohno Hematological Unit of Internal Mrdicine, Faculty of medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, Japan.
  • Shigeo Yokoyama Department of Pathology, Faculty of medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, Japan.
  • Sakuhei Fujiwara Department of Dematology, Faculty of medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita, Japan.
This report presents a case of bullous mycosis fungoides associated with an extensive ulcer and a severe leukemoid reaction. The rash began as indurated erythema which was always followed by ulceration. The rashes initially responded to radiation therapy, but multiple recurrences appeared. Several bullae appeared on the trunk during the course of the illness, without any evidence of paraneoplastic pemphigus. Finally, the ulcer covered a large part of the trunk, and the patient died of sepsis with an extreme leukocyte count of 118,000/μL. A bone marrow analysis revealed a leukemoid reaction and an autopsy revealed pseudomembranous colitis.

Supporting Agencies


Sato, S., Okamoto, O., Kawamoto, M., Oishi, M., Yada, N., Kohno, K., Yokoyama, S., & Fujiwara, S. (2011). Bullous mycosis fungoides associated with an extensive ulcer and a severe leukemoid reaction. Dermatology Reports, 3(3), e54. https://doi.org/10.4081/dr.2011.e54

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