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Complications of percutaneous endoscopic gastrostomy-jejunostomy for levodopa/carbidopa infusion in advanced Parkinson's disease

Ana Olivares, David Collado, Miguel Muñoz-Navas, Marta Calvo, Eduardo Olivo, Inmaculada Chico, Carlos Marra, Rafael Sánchez-Estella, Sarbelio Rodríguez, Josè Carlos Subtil, Luis Ramon Rábago
  • David Collado
    Gastroenterology Department, Hospital Severo Ochoa, Leganés, Madrid, Spain
  • Miguel Muñoz-Navas
    Gastroenterology Department, Clínica Universidad de Navarra, Pamplona, Spain
  • Marta Calvo
    Gastroenterology Department, Hospital Doce de Octubre, Madrid, Spain
  • Eduardo Olivo
    Surgical Deparment, Hospital Severo Ochoa, Leganés, Madrid, Spain
  • Inmaculada Chico
    Gastroenterology Department, Hospital Severo Ochoa, Leganés, Madrid, Spain
  • Carlos Marra
    Gastroenterology Department, Clínica Universidad de Navarra, Pamplona, Spain
  • Rafael Sánchez-Estella
    Surgical Deparment, Hospital Severo Ochoa, Leganés, Madrid, Spain
  • Sarbelio Rodríguez
    Gastroenterology Department, Hospital Doce de Octubre, Madrid, Spain
  • Josè Carlos Subtil
    Gastroenterology Department, Clínica Universidad de Navarra, Pamplona, Spain
  • Luis Ramon Rábago
    Gastroenterology Department, Hospital Severo Ochoa, Leganés, Madrid, Spain

Abstract

Continuous infusions of levodopa directly into the duodenum-yeyunum is an effective therapy to reduce daily off time in an advanced stage of Parkinson's disease, but it is not without complications, particularly device related problems. We present our experience in three Spanish hospitals with these complications, including a severe case with migration, several decubitus ulcers, and one case of perforation of the bowel and finally death.

Keywords

percutaneous endoscopic gastrostomy-tube, levodopa/carbidopa infusion in duodenum, intestinal obstruction, intestinal perforation, endoscopic extraction

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Submitted: 2011-08-16 20:04:14
Published: 2012-03-06 14:18:24
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