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DOI: http://dx.doi.org/10.4081/hi.2006.78

Discovering a new role for the atrial natriuretic peptide: A novel risk factor for cardiovascular diseases

Speranza Rubattu, Massimo Volpe

Abstract


Atrial natriuretic peptide, a diuretic, natriuretic and vasorelaxant hormone, is also involved in the regulation of cardiovascular remodeling and it has been recently shown to be significantly associated with higher occurrence of cardiovascular diseases. In fact, high plasma ANP levels predict higher mortality rate for cardiovascular events. Moreover, ANP gene alterations are associated with higher risk of cardiovascular intermediate phenotypes, such as left ventricular hypertrophy, and of cardiovascular diseases, such as stroke and hypertension. Thus, the characterization of ANP plasma levels, and of ANP genotype for known mutations can be proposed as an informative component of the individual cardiovascular risk profile.

Keywords


Atrial natriuretic peptide, Cardiovascular risk, Genetic

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Submitted: 2010-05-31 09:00:24
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Heart International [eISSN 2036-2579] is an Open Access, peer-reviewed journal published by PAGEPress, Pavia, Italy on behalf of Wichtig Editore, Milan, Italy. All credits and honors to PKP for their OJS.

 

 

 
 
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