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Autonomic dysfunction in Hodgkin and non-Hodgkin lymphoma. A paraneoplastic syndrome?

Franca Bilora, Francesco Veronese, Alice Zancan, Michela Biasiolo, Fabio Pomerri, Pier Carlo Muzzio
  • Francesco Veronese
    Affiliation not present
  • Alice Zancan
    Affiliation not present
  • Michela Biasiolo
    Affiliation not present
  • Fabio Pomerri
    Affiliation not present
  • Pier Carlo Muzzio
    Affiliation not present


We wanted to determine whether autonomic dysfunction in patients with lymphoma is related to chemotherapy or represent a paraneoplastic syndrome. 40 patients with current or cured Hodgkin or non-Hodgkin lymphoma and 40 healthy controls, matched for age, gender, hypertension and diabetes mellitus underwent autonomic evaluation (Deep Breath, Valsalva Maneuver, Hand Grip, Lying to Standing, Tilt Test). Current patients also suffering from diabetes or hypertension, or still on chemotherapy revealed autonomic changes, while cured or healthy subjects did not. Autonomic dysfunction in lymphoma is a transient manifestation of a paraneoplastic syndrome.


Lymphoma; autonomic dysfunction; paraneoplastic syndrome;

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Submitted: 2010-09-06 15:18:09
Published: 2010-11-26 12:46:15
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