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Hemoglobin Willamette (b51 Pro → Arg): case report and literature review

Orivaldo Alves Barbosa, Matheus Martins de Sousa Dias, Saymon Medeiros Távora, Gentil Claudino de Galiza Neto, Jacqueline Holanda de Souza, Herivaldo Ferreira da Silva
  • Matheus Martins de Sousa Dias
    School of Medicine, State University of Ceará, Brazil
  • Saymon Medeiros Távora
    School of Medicine, State University of Ceará, Brazil
  • Gentil Claudino de Galiza Neto
    Hematology Department, University Hospital Walter Cantídio, State University of Ceará, Fortaleza, Brazil
  • Jacqueline Holanda de Souza
    Hematology Department, University Hospital Walter Cantídio, State University of Ceará, Fortaleza, Brazil
  • Herivaldo Ferreira da Silva
    Department of Internal Medicine, Dr. César Cals General Hospital, Fortaleza, Brazil

Abstract

We report a case of hemoglobin (Hb) Willamette (β51 Pro → Arg) in the Hematology Department of a tertiary hospital in Fortaleza, Northeast of Brazil. A literature review of the cases described in health sciences databases using as a descriptor Hb Willamette was performed, revealing 12 reported cases, of which only one presented with anemia. Herein, we describe a case of a female 29 years old, with hemoglobinopathy Willamette presenting clinically with anemia, having the lowest hemoglobin rate of the published cases. The relatives of the patient were evaluated andthe patient’s mother corresponded to the first description of the association between Hb Willamette and HbC. Among the hemoglobinopathies, hemoglobin Willamette is an extremely rare disease; therefore it is important to analyze its clinical and laboratory manifestations for accurate diagnosis and assessment of potential interactions with other genetic variants.

Keywords

hemoglobins; hemoglobin Willamette; Anemia, hemolytic; Anemia, hemolytic, congenital

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Submitted: 2016-10-30 15:06:59
Published: 2017-03-01 09:22:14
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Copyright (c) 2017 Orivaldo Alves Barbosa, Matheus Martins de Sousa Dias, Saymon Medeiros Távora, Gentil Claudino de Galiza Neto, Jacqueline Holanda de Souza, Herivaldo Ferreira da Silva

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