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Acute myeloid leukemia with RAM immunophenotype: a pediatric case with unusual morphologic features

Miriam Conces, Rolla Abu-Arja, Suzanne Reed, Hemalatha G. Rangarajan, Terri L. Guinipero, Michael R. Loken, Lisa Eidenschink Brodersen, Samir B. Kahwash
  • Miriam Conces
    Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OH, United States
  • Rolla Abu-Arja
    Division of Hematology/Oncology and Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, OH, United States
  • Suzanne Reed
    Division of Hematology/Oncology and Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, OH, United States
  • Hemalatha G. Rangarajan
    Division of Hematology/Oncology and Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, OH, United States
  • Terri L. Guinipero
    Division of Hematology/Oncology and Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, OH, United States
  • Michael R. Loken
    Hematologics, Inc., Seattle, WA, United States
  • Lisa Eidenschink Brodersen
    Hematologics, Inc., Seattle, WA, United States

Abstract

The RAM immunophenotype has been recently described as a subtype of acute myelogenous leukemia (AML) that is characterized clinically by extremely poor prognosis. We present a case of AML with RAM immunophenotype in a 5-year-old patient that resulted in poor outcome despite early hematopoietic cell transplant. We describe the unusual morphologic features that, along with the distinct immunophenotype, may provide initial diagnostic clues and further justify the classification of this AML variant as a rather distinct subtype.

Keywords

Acute myeloid leukemia; Pediatric; RAM

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Submitted: 2017-01-20 21:25:08
Published: 2017-06-14 08:23:07
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Copyright (c) 2017 Miriam Conces, Rolla Abu-Arja, Suzanne Reed, Hemalatha G Rangarajan, Terri L Guinipero, Michael R Loken, Lisa Eidenschink Brodersen, Samir B Kahwash

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