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Expression of some ATP-binding cassette transporters in acute myeloid leukemia

Antonella Maria Salvia, Flavia Cuviello, Sabrina Coluzzi, Roberta Nuccorini, Immacolata Attolico, Sara Pasquina Pascale, Faustino Bisaccia, Michele Pizzuti, Angela Ostuni
  • Antonella Maria Salvia
    Department of Sciences, University of Basilicata, Potenza, Italy
  • Flavia Cuviello
    Department of Sciences, University of Basilicata, Potenza, Italy
  • Sabrina Coluzzi
    Department of Hematology, San Carlo Hospital, Potenza, Italy
  • Roberta Nuccorini
    Department of Hematology, San Carlo Hospital, Potenza, Italy
  • Immacolata Attolico
    Department of Hematology, San Carlo Hospital, Potenza, Italy
  • Sara Pasquina Pascale
    Department of Hematology, San Carlo Hospital, Potenza, Italy
  • Faustino Bisaccia
    Department of Sciences, University of Basilicata, Potenza, Italy
  • Michele Pizzuti
    Department of Hematology, San Carlo Hospital, Potenza, Italy

Abstract

Hematopoietic cells express ATP binding cassette (ABC) transporters in relation to different degrees of differentiation. One of the known multidrug resistance mechanisms in acute myeloid leukemia (AML) is the overexpression of efflux pumps belonging to the superfamily of ABC transporters such as ABCB1, ABCG2 and ABCC1. Although several studies were carried out to correlate ABC transporters expression with drug resistance, little is known about their role as markers of diagnosis and progression of the disease. For this purpose we investigated the expression, by real-time PCR, of some ABC genes in bone marrow samples of AML patients at diagnosis and after induction therapy. At diagnosis, ABCG2 was always down-regulated, while an up regulated trend for ABCC1 was observed. After therapy the examined genes showed a different expression trend and approached the values of healthy subjects suggesting that this event could be considered as a marker of AML regression. The expression levels of some ABC transporters such as ABCC6, seems to be related to gender, age and to the presence of FLT3/ITD gene mutation.

Keywords

Acute Myeloid Leukemia; Multidrug Resistance; ABC transporters; ABCC6

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Submitted: 2017-09-13 21:31:38
Published: 2017-12-22 10:55:01
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Copyright (c) 2017 Antonella Maria Salvia, Flavia Cuviello, Sabrina Coluzzi, Roberta Nuccorini, Immacolata Attolico, Sara Pasquina Pasquale, Faustino Bisaccia, Michele Pizzuti, Angela Ostuni

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