Cover Image

Tuberculosis biomarkers: from diagnosis to protection

Delia Goletti, Elisa Petruccioli, Simone A. Joosten, Tom H.M. Ottenhoff
  • Delia Goletti
    Translational Research Unit, Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases, L. Spallanzani, Rome, Italy | delia.goletti@inmi.it
  • Elisa Petruccioli
    Translational Research Unit, Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases, L. Spallanzani, Rome, Italy
  • Simone A. Joosten
    Department of Infectious Diseases, Leiden University Medical Centre, Netherlands
  • Tom H.M. Ottenhoff
    Department of Infectious Diseases, Leiden University Medical Centre, Netherlands

Abstract

New approaches to control tuberculosis (TB) worldwide are needed. In particular, new tools for diagnosis and new biomarkers are required to evaluate both pathogen and host key elements of the response to infection. Non-sputum based diagnostic tests, biomarkers predictive of adequate responsiveness to treatment, and biomarkers of risk of developing active TB disease are major goals. Here, we review the current state of the field. Although reports on new candidate biomarkers are numerous, validation and independent confirmation are rare. Efforts are needed to reduce the gap between the exploratory up-stream identification of candidate biomarkers, and the validation of biomarkers against clear clinical endpoints in different populations. This will need a major commitment from both scientists and funding bodies.

Keywords

Tuberculosis; biomarkers

Full Text:

PDF
HTML
Submitted: 2016-04-29 11:48:06
Published: 2016-06-24 10:17:42
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
1660

Views:
PDF
845
HTML
1385

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2016 Delia Goletti, Elisa Petruccioli, Simone A. Joosten, Tom H.M. Ottenhoff

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185