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Cognitive effects of lamotrigine versus topiramate as adjunctive therapy in older adults with epilepsy

Steve S. Chung, Susan Kerls, Ann Hammer, Robert Kustra

Authors information
  • Steve S. Chung
    Barrow Neurological Institute, United States. sschung@chw.edu
  • Susan Kerls
    Neuroscience Development Center, GlaxoSmithKline, Research Triangle Park, NC, USA, United States.
  • Ann Hammer
    Neuroscience Development Center, GlaxoSmithKline, Research Triangle Park, NC, USA, United States.
  • Robert Kustra
    Neuroscience Development Center, GlaxoSmithKline, Research Triangle Park, NC, USA, United States.

Abstract


Older individuals may be more susceptible to cognitive side effects of antiepileptic drugs than are younger adults. This randomized, double-blind study compared the cognitive effects of lamotrigine (median maintenance dosage, 500.0 mg/d) and topiramate (median maintenance dosage, 300.0 mg/d) as adjunctive therapy for 16 weeks in patients ≥50 years of age. Fifty-one patients (lamotrigine, n=25; topiramate, n=26) were enrolled, and 28 patients (lamotrigine, n=15; topiramate, n=13) completed the study. In a combined analysis of all cognitive tests performed, no significant differences between treatment groups were noted. However, analyses of individual cognitive test results revealed that lamotrigine-treated patients had significantly better results on the Controlled Oral Word Association Test and the Symbol-Digit Modalities Test, whereas topiramate-treated patients had significantly more favorable results on the Digit Cancellation Test and the Rey Auditory-Verbal Learning Test. Larger studies are needed to further clarify the differences in the cognitive effects of lamotrigine and topiramate in older patients.

Keywords


Epilepsy; Lamotrigine; Topiramate; Cognition

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Submitted: 2009-03-18 22:56:53
Published: 2009-07-08 08:23:00
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Neurology International [eISSN 2035-8377] is an Open Access, peer-reviewed journal published by PAGEPress, Pavia, Italy. All credits and honors to PKP for their OJS.

 
 
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