Cover Image

Autism Spectrum Disorder: Correlation between aberrant behaviors, EEG abnormalities and seizures

Michelle Elena Hartley-McAndrew, Arie Weinstock
  • Michelle Elena Hartley-McAndrew
    Women and Children's Hospital of Buffalo, United States | mhmcandrew@thejni.org
  • Arie Weinstock
    Women and Children's Hospital of Buffalo, United States

Abstract

The relationship between epilepsy, epileptiform discharges, cognitive, language and behavioral symptoms is not clearly understood. Since difficulties with socialization and maladaptive behaviors are found in children with Autism Spectrum Disorder (ASD), we inquired whether epileptiform activity and seizures are associated with adverse behavioral manifestations in this population. We reviewed our EEG database between 1999-2006, and identified 123 children with ASD. EEG abnormalities were found in 39 children (31%). A control group of age and gender matched ASD children with normal EEG’s was obtained. Packets of questionnaires including the Vineland Adaptive Behavior Scale II (VABS), Aberrant Behavior Checklist (ABC) and the Childhood Autism Rating Scale (CARS) were sent by mail. Out of 21 packets received, 11 had normal and 10 had abnormal EEG’s. There were no statistically significant differences in behavior between the two groups. Statistical analysis of discharge location and frequency did not reveal a significant trend. However, children with ASD and seizures had statistically significant lower scores in VABS daily living (P=0.009) and socialization (P=0.007) as compared to those without seizures. ASD children with seizures had higher ABC levels of hyperactivity and irritability. Differences in irritability scores nearly reached statistical significance (P=0.058). There was no significant difference in the degree of CARS autism rating between the groups. Our study did not reveal statistically significant differences in behaviors between ASD children with and without EEG abnormalities. However, ASD children with seizures revealed significantly worse behaviors as compared to counterparts without seizures.

Keywords

Autism Spectrum Disorder, Behavior, EEG, Epilepsy

Full Text:

PDF
HTML
Submitted: 2010-02-22 03:05:05
Published: 2010-04-29 09:13:46
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
1953

Views:
PDF
252
HTML
13432

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2010 Michelle Elena Hartley-McAndrew, Arie Weinstock

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185