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Anti-glomerular basement membrane disease, ulcerative colitis, and primary sclerosing cholangitis: link or co-incidence?

Emilie Pinçon, Guillaume Bouguen, Guillaume Coiffier, Joseph Rivalan, Patrick Le Pogamp, Nathalie Rioux-Leclercq, Cecile Vigneau

Authors information
  • Guillaume Bouguen
    Service de gastroenterologie, CHU Pontchaillou, Rennes, France, France.
  • Guillaume Coiffier
    Service de néphrologie, CHU Pontchaillou, Rennes, France, France.
  • Joseph Rivalan
    Service de néphrologie, CHU Pontchaillou, Rennes, France, France.
  • Patrick Le Pogamp
    Service de néphrologie, CHU Pontchaillou, Rennes, France, France.
  • Nathalie Rioux-Leclercq
    Service d’anatomie et cytologie pathologiques, CHU Pontchaillou, Rennes, France; UMR 6061/IFR 140, Université Rennes 1, Rennes, France, France.
  • Cecile Vigneau
    Service de néphrologie, CHU Pontchaillou, Rennes, France; UMR 6061/IFR 140, Université Rennes 1, Rennes, France, France.

Abstract


Ulcerative colitis, primary sclerosing cholangitis, and anti-glomerular basement membrane disease (anti-GBM) are three rare immune diseases with incompletely understood pathogenic mechanisms. We describe here the case of a 29-year-old man with ulcerative colitis and primary sclerosing cholang­itis who, eight years later, developed anti-GBM disease with destruction of all glomeruli leading to end-stage kidney disease. Association of these three immune diseases in the same patient has never been described. Because HLA-mediated susceptibility cannot be incriminated completely in our case, we hypothesize that environmental factors or previous immunosuppressive treatment used might be the link.

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Submitted: 2010-04-22 15:09:55
Published: 2010-07-20 14:17:03
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Nephrology Reviews [eISSN 2035-813X] is an Open Access, peer-reviewed journal published online by PAGEPress, Pavia, Italy on behalf of Wichtig Editore, Milan, Italy. All credits and honors to PKP for their OJS.

 
 
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