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DOI: http://dx.doi.org/10.4081/nr.2010.e10

Anti-glomerular basement membrane disease, ulcerative colitis, and primary sclerosing cholangitis: link or co-incidence?

Emilie Pinçon, Guillaume Bouguen, Guillaume Coiffier, Joseph Rivalan, Patrick Le Pogamp, Nathalie Rioux-Leclercq, Cecile Vigneau


Ulcerative colitis, primary sclerosing cholangitis, and anti-glomerular basement membrane disease (anti-GBM) are three rare immune diseases with incompletely understood pathogenic mechanisms. We describe here the case of a 29-year-old man with ulcerative colitis and primary sclerosing cholang­itis who, eight years later, developed anti-GBM disease with destruction of all glomeruli leading to end-stage kidney disease. Association of these three immune diseases in the same patient has never been described. Because HLA-mediated susceptibility cannot be incriminated completely in our case, we hypothesize that environmental factors or previous immunosuppressive treatment used might be the link.

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Submitted: 2010-04-22 15:09:55
Published: 2010-07-20 14:17:03
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