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Cell therapy in bone healing disorders

Marcus Jäger, Philippe Hernigou, Christoph Zilkens, Monika Herten, Xinning Li, Johannes Fischer, Rüdiger Krauspe

Authors information
  • Philippe Hernigou
    Affiliation not present.
  • Christoph Zilkens
    Affiliation not present.
  • Monika Herten
    Affiliation not present.
  • Xinning Li
    Affiliation not present.
  • Johannes Fischer
    Affiliation not present.
  • Rüdiger Krauspe
    Affiliation not present.


In addition to osteosynthetic stabilizing techniques and autologous bone transplantations, so-called orthobiologics play an increasing role in the treatment of bone healing disorders. Besides the use of various growth factors, more and more new data suggest that cell-based therapies promote local bone regeneration. For ethical and biological reasons, clinical application of progenitor cells on the musculoskeletal system is limited to autologous, postpartum stem cells. Intraoperative one-step treatment with autologous progenitor cells, in particular, delivered promising results in preliminary clinical studies. This article provides an overview of the rationale for, and characteristics of the clinical application of cell-based therapy to treat osseous defects based on a review of existing literature and our own experience with more than 100 patients. Most clinical trials report successful bone regeneration after the application of mixed cell populations from bone marrow. The autologous application of human bone marrow cells which are not expanded ex vivo has medico-legal advantages. However, there is a lack of prospective randomized studies including controls for cell therapy for bone defects. Autologous bone marrow cell therapy seems to be a promising treatment option which may reduce the amount of bone grafting in future.


stem cell; cell therapy; bone defect; osteoblast

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Submitted: 2010-08-03 12:41:11
Published: 2010-09-10 16:38:28
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Orthopedic Reviews [eISSN 2035-8164] is an Open Access, peer-reviewed journal published by PAGEPress®, Pavia, Italy. All credits and honors to PKP for their OJS.


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