Cover Image

Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial

Seyed Mansoor Rayegani, Seyed Ahmad Raeissadat, Morteza Sanei Taheri, Marzieh Babaee, Mohammad Hassan Bahrami, Dariush Eliaspour, Elham Ghorbani
  • Seyed Mansoor Rayegani
    Physical Medicine and Rehabilitation Department, Shohada-e-Tajrish Hospital, Iran, Islamic Republic of
  • Seyed Ahmad Raeissadat
    Physical Medicine and Rehabilitation Department, Shahid Modarres Hospital, Iran, Islamic Republic of
  • Morteza Sanei Taheri
    Radiology Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of
  • Marzieh Babaee
    Physical Medicine and Rehabilitation Department, Shohada-e-Tajrish Hospital, Iran, Islamic Republic of | rambabaee@yahoo.com
  • Mohammad Hassan Bahrami
    Physical Medicine and Rehabilitation Department, Shohada-e-Tajrish Hospital, Iran, Islamic Republic of
  • Dariush Eliaspour
    Physical Medicine and Rehabilitation Department, Shohada-e-Tajrish Hospital, Iran, Islamic Republic of
  • Elham Ghorbani
    Physical Medicine and Rehabilitation Department, Shohada-e-Tajrish Hospital, Iran, Islamic Republic of

Abstract

We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exercise was prescribed. In the PRP group, two courses of leukocyte rich PRP (5.6 fold higher platelet concentration) with a 4-week interval was injected. For each participant, Western Ontario and McMaster University’s Arthritis Index (WOMAC) and the SF-36 questionnaire (Farsi version) were filled at the baseline and 6 months after treatments. Thirty-one patients in the PRP group and 31 patients in the control group were studied. Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05). This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.

Keywords

platelet rich plasma, therapeutic exercise, knee osteoarthritis

Full Text:

PDF
HTML
Submitted: 2014-03-25 16:51:36
Published: 2014-09-18 09:35:51
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
1697

Views:
PDF
548
HTML
369

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2014 Seyed Mansoor Rayegani, Seyed Ahmad Raeissadat, Morteza Sanei Taheri, Marzieh Babaee, Mohammad Hassan Bahrami, Dariush Eliaspour, Elham Ghorbani

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185