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DOI: http://dx.doi.org/10.4081/pr.2011.e15

Effectiveness of cyclosporine and mycophenolate mofetil in a child with refractory evans syndrome

Piero Farruggia, Alessandra Macaluso, Serena Tropia, Selene Genova, Olivia Paolicchi, Floriana Di Marco, Paolo D'Angelo


Evans Syndrome is a rare autoimmune disease consisting of hemolytic anemia, thrombocytopenia and/or neutropenia. It may be associated with other autoimmune or lymphoproliferative diseases. Its course can be extremely serious and, rarely, even life-threatening; thus it represents a excellent treatment challenge for the pediatric hematologist. First line treatment consists of steroids and/or immunoglobulin; further therapy with rituximab, vincristine, cyclophosphamide and other immunosuppressive drugs can be considered in unresponsive patients. We describe a baby with refractory Evans Syndrome that was cured by prolonged administration of mycophenolate mofetil and remained disease-free for 4 years after the discontinuation of treatment.


Evans’ syndrome, Cyclosporine, Mycophenolate mofetil, Treatment, Outcome

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Submitted: 2011-03-24 23:02:10
Published: 2011-05-16 09:07:57
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