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DOI: http://dx.doi.org/10.4081/pr.2011.e28

B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia

Annelieke A.A. van der Linde, Ellen J.H. Schatorjé, Annemieke M. van der Weij, Eugenie F.A. Gemen, Esther de Vries

Abstract


We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower reconstitution after the second rituximab course, especially of non-switched and switched memory B-lymphocytes, and a temporary decline in IgM below age-matched reference values.

Keywords


Autoimmune hemolytic anemia; Rituximab; Child; Immune reconstitution; B-lymphocytes

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Submitted: 2011-05-12 10:01:36
Published: 2011-12-13 14:04:25
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