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B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia

Annelieke A.A. van der Linde, Ellen J.H. Schatorjé, Annemieke M. van der Weij, Eugenie F.A. Gemen, Esther de Vries

Authors information
  • Annelieke A.A. van der Linde
    Department of Pediatrics, Jeroen Bosch Hospital, ‘s-Hertogenbosch, Netherlands.
  • Ellen J.H. Schatorjé
    Department of Pediatrics, Jeroen Bosch Hospital, ‘s-Hertogenbosch, Netherlands.
  • Annemieke M. van der Weij
    Department of Pediatrics, Jeroen Bosch Hospital, ‘s-Hertogenbosch, Netherlands.
  • Eugenie F.A. Gemen
    Laboratory of Hematology and Clinical Chemistry, Jeroen Bosch Hospital, ‘s-Hertogenbosch, Netherlands.
  • Esther de Vries
    Department of Pediatrics, Jeroen Bosch Hospital, ‘s-Hertogenbosch, Netherlands. e.d.vries@jbz.nl

Abstract


We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower reconstitution after the second rituximab course, especially of non-switched and switched memory B-lymphocytes, and a temporary decline in IgM below age-matched reference values.

Keywords


Autoimmune hemolytic anemia; Rituximab; Child; Immune reconstitution; B-lymphocytes

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Submitted: 2011-05-12 10:01:36
Published: 2011-12-13 14:04:25
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Pediatric Reports [eISSN 2036-7503] is an Open Access, peer-reviewed journal published by PAGEPress, Pavia, Italy. All credits and honors to PKP for their OJS.

 
 
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