Login   |   Register
Cover Image


DOI: http://dx.doi.org/10.4081/pr.2011.s2.e6

How does the NPM1 mutant induce leukemia?

Paolo Sportoletti

Abstract


NPM1 is the most frequently mutated gene in AML and the role of the NPM1 mutant in acute myeloid leukemia along with its leukemogenic potential are still under investigation. NPM1 genetic alterations can contribute to leukemogenesis through the direct oncogenic effect of the mutant protein and the concomitant loss of one functional allele. Npm1 loss determines tumor development in the mouse while in human NPM1 maps in a chromosomal region frequently loss in myelodysplastic syndrome (MDS). The NPM1 mutant cytoplasmic delocalization in leukemic blasts alters multiple cellular pathways through either loss or gain of function effects on different protein partners. Here we discuss the most relevant studies on the role of the NPM1 molecule in hematological malignancies and both in vitro and in vivo studies that are trying to elucidate the way by which the NPM1 mutation induces leukemia.

Full Text:

PDF

Submitted: 2011-06-17 17:38:26
Published: 2011-06-17 17:59:37
Search for citations in Google Scholar
Related articles: Google Scholar


 

Pediatric Reports [eISSN 2036-7503] is an Open Access, peer-reviewed journal published by PAGEPress, Pavia, Italy. All credits and honors to PKP for their OJS.

 
 
© PAGEPress 2008-2013     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185