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The role of interleukin-6 in the early diagnosis of sepsis in premature infants

Mehrdad Mirzarahimi, Manouchehr Barak, Abdolkarim Eslami, Afsaneh Enteshari-Moghaddam
  • Mehrdad Mirzarahimi
    Department of Pediatrics, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran, Islamic Republic of
  • Manouchehr Barak
    Department of Pediatrics, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran, Islamic Republic of
  • Abdolkarim Eslami
    Department of Pediatrics, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran, Islamic Republic of
  • Afsaneh Enteshari-Moghaddam
    Department of Pediatrics, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran, Islamic Republic of | biostat.f@gmail.com

Abstract

Septicemia is one of the major causes of mortality and morbidity in newborns. The aim of this study was to investigate the role of interleukin-6 (IL-6) in the early diagnosis of Sepsis in premature newborns. This cross-sectional study was conducted on preterm infants admitted to NICU of Hospital Buali in Ardabil city, Iran. C-reactive protein (CRP), IL-6 and complete blood count tests have been done in baseline, third and seventh day. Collected data analyzed by one-sample t-test, repeated measures and ANOVA in SPSS.21. The mean of IL-6 in the first and third day after hospitalization was significantly more than normal value. The mean of CRP in the third and seventh day after hospitalization significantly more than normal value. We found that increasing in IL-6 level can occur earlier than CRP and it can be used as a good index in early sepsis diagnosis compare than CRP.

Keywords

Neonatal Sepsis, Premature newborns, Interleukin-6, CRP

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Submitted: 2017-07-10 07:07:43
Published: 2017-10-06 11:23:11
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Copyright (c) 2017 Mehrdad Mirzarahimi, Manouchehr Barak, Abdolkarim Eslami, Afsaneh Enteshari-Moghaddam

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