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A rare case of an aldosterone secreting metastatic adrenocortical carcinoma and papillary thyroid carcinoma in a 31-year-old male

Stephen M. Wanta, Marina Basina, Steven D. Chang, Daniel T. Chang, James M. Ford, Ralph Greco, Kerry Kingham, Robert E. Merritt, Pamela L. Kunz

Authors information
  • Stephen M. Wanta
    Georgetown University School of Medicine, Washington DC, United States.
  • Marina Basina
    Stanford University School of Medicine, Stanford, CA, United States.
  • Steven D. Chang
    Stanford University School of Medicine, Stanford, CA, United States.
  • Daniel T. Chang
    Stanford University School of Medicine, Stanford, CA, United States.
  • James M. Ford
    Stanford University School of Medicine, Stanford, CA, United States.
  • Ralph Greco
    Stanford University School of Medicine, Stanford, CA, United States.
  • Kerry Kingham
    Stanford University School of Medicine, Stanford, CA, United States.
  • Robert E. Merritt
    Stanford University School of Medicine, Stanford, CA, United States.
  • Pamela L. Kunz
    Stanford University School of Medicine, Stanford, CA, United States. pkunz@stanford.edu

Abstract


We report a rare synchronous presentation of adrenocortical carcinoma (ACC) and papillary thyroid carcinoma (PTC). A 31-year-old male first presented with a large left adrenal mass that was identified during the workup for refractory hypertension due to hyperaldosteronism. The mass was removed surgically with pathology showing ACC. The patient was then treated with adjuvant radiation therapy and mitotane chemotherapy. Four months post ACC resection, metastatic ACC to the right upper lung and PTC in the left lobe of the thyroid were found in surveillance imaging. He subsequently developed pulmonary, contralateral adrenal and brain metastases from his ACC. Li Fraumeni syndrome and Multiple Endocrine Neoplasia Type I (MEN I) were considered, but testing of both P53 and menin genes showed no mutation. We also performed a review of the literature and found three similar cases, however gene mutation analysis was not performed.

Keywords


Adrenocortical carcinoma, papillary thyroid carcinoma, hereditary cancer syndrome

Full Text





Submitted: 2011-08-08 03:53:09
Published: 2011-12-13 14:33:54
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Rare Tumors [ISSN 2036-3605, eISSN 2036-3613] is an Open Access, peer-reviewed journal published by PAGEPress, Pavia, Italy. All credits and honors to PKP for their OJS.

 

 

 

 
 
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