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Large plasmacytoma occupying the upper limb in a myeloma patient

Junichiro Takano, Kensuke Ohikata, Daisuke Nagase, Toru Igari, Kazuhiko Natori, Shotaro Hagiwara
  • Junichiro Takano
    Division of Hematology, Department of Internal Medicine, National Center for Global Health and Medicine, Tokyo, Japan | junichiro.takano@riken.jp
  • Kensuke Ohikata
    Division of Pathology, National Center for Global Health and Medicine, Tokyo, Japan
  • Daisuke Nagase
    Division of Hematology and Oncology, Department of Internal Medicine, Toho University Medical Center Oomori Hospital, Tokyo, Japan
  • Toru Igari
    Division of Pathology, National Center for Global Health and Medicine, Tokyo, Japan
  • Kazuhiko Natori
    Division of Hematology and Oncology, Department of Internal Medicine, Toho University Medical Center Oomori Hospital, Tokyo, Japan
  • Shotaro Hagiwara
    Division of Hematology, Department of Internal Medicine, National Center for Global Health and Medicine, Tokyo, Japan

Abstract

Extramedullary disease (EMD) is an issue for patients with multiple myeloma (MM), since extramedullary spread of MM is associated with an aggressive course and a poor prognosis. Moreover, the mechanism of EMD development is uncertain. Here, we present extensive extramedullary plasmacytoma occupying the left upper limb of a 66- year-old female patient with MM with an extremely aggressive course and multiple visceral organ involvement without bone marrow infiltration or plasma cell leukemia. EMD of this large size is extremely rare and this case may provide a clue for better understanding of clinical features of EMD in MM.

Keywords

Multiple myeloma; Extramedullary diseases; Tumor heterogeneity

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Submitted: 2015-02-10 18:31:04
Published: 2017-03-30 11:29:37
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Copyright (c) 2017 Junichiro Takano, Kensuke Ohikata, Daisuke Nagase, Toru Igari, Kazuhiko Natori, Shotaro Hagiwara

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