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Immunohistochemical diagnosis of primary cardiac leiomyosarcoma in a Latin American patient

Ruben Blachman-Braun, Carlos Manuel Aboitiz-Rivera, Alberto Aranda-Fraustro, Adrián Ransom-Rodríguez, Mario Enrique Baltazares-Lipp, Jorge Manuel Catrip-Torres, Jesús Octavio Martínez-Reding
  • Ruben Blachman-Braun
    Centro de Investigación en Ciencias de la Salud, Facultad de Ciencias de la Salud, Universidad Anáhuac México Norte, Mexico | rubenblachman@gmail.com
  • Carlos Manuel Aboitiz-Rivera
    Echocardiography and Hemodynamics Service, Instituto Nacional de Enfermedades Respiratorias, Tlalpan, Mexico City, Mexico
  • Alberto Aranda-Fraustro
    Department of Pathology, Instituto Nacional de Cardiología Ignacio Chavez, Mexico City, Mexico
  • Adrián Ransom-Rodríguez
    Department of Hepatopancreatobiliary Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
  • Mario Enrique Baltazares-Lipp
    Echocardiography and Hemodynamics Service, Instituto Nacional de Enfermedades Respiratorias, Tlalpan, Mexico City, Mexico
  • Jorge Manuel Catrip-Torres
    Department of Cardiovascular Surgery, Instituto Nacional de Cardiología Ignacio Chavez, Mexico City, Mexico
  • Jesús Octavio Martínez-Reding
    Department of Cardiology, Instituto Nacional de Cardiología Ignacio Chavez, Mexico City, Mexico

Abstract

Primary cardiac malignancies are rare entities. Although sarcomas enclosed the main group of malignant heart neoplasms, primary cardiac leiomyosarcomas are extremely rare and constitutes less than 8% of cardiac tumors. Leiomyosarcoma usually originates from the pulmonary veins and have a worm-like shaped structure. In this article, we present a case of a 40-year-old Hispanic man diagnosed with a cardiac tumor who underwent surgical resection, during pathological examination the tissue samples were consistent with a malignancy of mesenchymal origin that contained irregular bundles of spindle cells. Subsequent immunohistochemical study categorized the mass as a primary heart leiomyosarcoma with positive smooth muscle actin and muscle specific actin. As usual in this type of malignancy, patient’s clinical status declined overtime, recurrence was diagnosed two months after surgery, and four months after the procedure the patient was discharge for palliative care.

Keywords

Primary cardiac tumors; leiomyosarcoma; spindle cells; smooth muscle actin; muscle specific actin;

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Submitted: 2016-06-29 05:57:58
Published: 2017-03-28 16:27:46
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Copyright (c) 2017 Ruben Blachman-Braun, Carlos Manuel Aboitiz-Rivera, Alberto Aranda-Fraustro, Adrián Ransom-Rodríguez, Mario Enrique Baltazares-Lipp, Jorge Manuel Catrip-Torres, Jesús Octavio Martínez-Reding

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