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Osteosarcoma of the larynx: treatment outcomes and patterns of failure analysis

Nathan R. Bennion, Michael J. Baine, Timothy Malouff, Weining Zhen
  • Nathan R. Bennion
    Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, United States | nathan.bennion@unmc.edu
  • Michael J. Baine
    Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, United States
  • Timothy Malouff
    Creighton University Medical Center, Omaha, NE, United States
  • Weining Zhen
    Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, United States

Abstract

The incidence of laryngeal sarcoma is exceedingly low with osteosarcomas of the larynx being rarer still, comprising less than 1% of all associated malignancies. To date, only 32 cases have been reported since this pathologic entity was first described in 1942. In this article, we discuss the most recent case of laryngeal osteosarcoma in a patient presenting with respiratory distress found to be due to a tumor mass arising from her cricoid cartilage. We further summarize current knowledge regarding the epidemiology, presentation, and diagnosis of this uncommon disease. Lastly, we synthesize all available information regarding treatment and outcomes of the 32 previously described cases of osteosarcoma of the larynx as well as the presently described case in an attempt to offer some insight regarding optimal treatment in future cases.

Keywords

Larynx, Osteosarcoma, Chemoradiation, Surgery

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Submitted: 2016-11-02 17:23:31
Published: 2017-03-24 11:38:27
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Copyright (c) 2017 Nathan R. Bennion, Michael J. Baine, Timothy Malouff, Weining Zhen

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