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A case report of an extremely rare and aggressive tumor: primary malignant pericardial mesothelioma

Authors
Xiaolan Feng, Liena Zhao, Guangming Han, Moosa Khalil, Francis Green, Travis Ogilvie, Vanessa Krause

Authors information
  • Xiaolan Feng
    Internal Medicine Residency Training Program, Department of Medicine, Department of Medical Oncology, University of Calgary, Calgary, Alberta, Canada. fxiaolan@ucalgary.ca
  • Liena Zhao
    Department of Pathology, University of Calgary, Calgary, Alberta, Canada.
  • Guangming Han
    Department of Pathology, University of Calgary, Calgary, Alberta, Canada.
  • Moosa Khalil
    Department of Pathology, University of Calgary, Calgary, Alberta, Canada.
  • Francis Green
    Department of Pathology, University of Calgary, Calgary, Alberta, Canada.
  • Travis Ogilvie
    Department of Pathology, University of Calgary, Calgary, Alberta, Canada.
  • Vanessa Krause
    Department of Medical Oncology, University of Calgary, Calgary, Alberta, Canada.

Abstract


Primary pericardial malignant mesothelioma (PMPM) is extremely rare with an incidence less than 0.0022%. It comprises 0.7% of all mesothelioma cases. To date, approximately 350 cases of pericardial mesothelioma have been reported in the literature. Its typical presentation is insidious, with nonspecific signs and symptoms, and usually results in constrictive pericarditis, cardiac tamponade and congestive heart failure either by a serous effusion or by direct tumorous constriction of the heart. With the exception of several case reports, the outcome is uniformly fatal, and patients typically die within six months of diagnosis. Here we report a 72-year-old Caucasian male with persistent pericardial and pleural effusion. He was diagnosed with PMPM after pericardectomy. He had only one cycle of chemotherapy with cisplatin and pemetrexed. He developed acute kidney injury as result of chemotherapy. He died 1 month after diagnosis and 6 months after the first symptoms.

Keywords


Medicine; oncology; primary pericardical malignant mesothelioma

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Submitted: 2011-11-18 19:45:47
Published: 2012-04-13 17:52:57
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Rare Tumors [ISSN 2036-3605, eISSN 2036-3613] is an Open Access, peer-reviewed journal published by PAGEPress®, Pavia, Italy. All credits and honors to PKP for their OJS.
 
 
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