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Effect of passive immunization by anti-gingipain IgY on periodontal health of dogs


 
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1. Title Title of document Effect of passive immunization by anti-gingipain IgY on periodontal health of dogs
 
2. Creator Author's name, affiliation, country Rahman A.K.M. Shofiqur; Immunology Research Institute, GHEN Corporation; Japan
 
2. Creator Author's name, affiliation, country El-Sayed M. Ibrahim; Immunology Research Institute, GHEN Corporation; Japan
 
2. Creator Author's name, affiliation, country Rie Isoda; Japan
 
2. Creator Author's name, affiliation, country Kouji Umeda; Japan
 
2. Creator Author's name, affiliation, country Van Sa Nguyen; Japan
 
2. Creator Author's name, affiliation, country Yoshikatsu Kodama; Japan
 
3. Subject Discipline(s) Veterinary; Animals; Medicine;
 
3. Subject Keyword(s) Gingipain; IgY; Periodontitis; Pet; Porphyromonas gingivalis
 
4. Description Abstract Anti-gingipain IgY (IgY-GP), known as hyperimmune γ-livetin from egg yolk, inhibits the enzyme activity, growth and adherence of Porphyromonas gingivalis to gingival epithelial cells. Our objective was to evaluate the efficacy of IgY-GP on periodontal health of dogs. IgY-GP was prepared from the egg yolk of hens immunized with the gingipain from Porphyromonas gingivalis ATCC 33277. Two in vivo trial models were conducted on 15 adult dogs with periodontitis by giving IgY-GP-supplemented dog feed for 8 weeks and direct application of the IgY in dental ointment to the periodontal pockets at weekly interval for 4 weeks. Clinical parameters including gingivitis, periodontitis, oral health index, bleeding on probe (BOP), pocket depth (PD), and dental calculus removal pattern for selected premolar teeth were recorded at baseline, 4 and 8 weeks post treatment.IgY-GP showed strong cross-reactivity with gingipain from Porphyromonas gulae and inhibited the enzyme activity in vitro. In the dog trials, IgY-GP resulted in significant improvement of oral health parameters including gingivitis and periodontitis scores, BOP, dental calculus removal. No adverse events during and after antibody applications were noted. Oral immunotherapy by using IgY-GP is a new promising alternative to conventional preventive and therapeutic methods to improve oral health status in dogs.
 
5. Publisher Organizing agency, location PAGEPress Publications
 
6. Contributor Sponsor(s) Immunology Research Institute, Ghen Corporation
 
7. Date (YYYY-MM-DD) 2011-09-27
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier http://www.pagepress.org/journals/index.php/vsd/article/view/2204
 
10. Identifier Digital Object Identifier http://dx.doi.org/10.4081/vsd.2011.e8
 
11. Source Title; vol., no. (year) Veterinary Science Development; Vol 1, No 1 (2011)
 
12. Language English=en en
 
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15. Rights Copyright and permissions Copyright (c)