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Proteus syndrome: a case report and a case study review in China

Xi-Bao Zhang, Chang-Xing Li, Yu-Qing He, San-Quan Zhang, Yan-Xia Cai
  • Chang-Xing Li
    Affiliation not present
  • Yu-Qing He
    Affiliation not present
  • San-Quan Zhang
    Affiliation not present
  • Yan-Xia Cai
    Affiliation not present


Proteus syndrome (PS) is a rare and sporadic disorder characterized by overgrowth of multiple tissues and a propensity to develop particular neoplasms. The clinical manifestations of PS include macrodactyly, vertebral abnormalities, asymmetric limb overgrowth and length discrepancy, hyperostosis, abnormal and asymmetric fat distribution, asymmetric muscle development, connective tissue nevi, and vascular malformations. We report a 16-year old female patient who manifested a number of these complications and review the Chinese literature about the diagnosis, natural history, and management of PS.


Proteus syndrome, clinical manifestation, diagnosis

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Submitted: 2009-11-02 15:35:27
Published: 2010-02-10 07:46:18
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Copyright (c) 2010 Xi-Bao Zhang, Chang-Xing Li, Yu-Qing He, San-Quan Zhang, Yan-Xia Cai

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