Angina bullosa hemorrhagica: report of 11 cases

  • Julieta Ruiz Beguerie | Dermatology Department, Austral University Hospital, Austral University, Buenos Aires, Argentina.
  • Silvina Gonzalez Dermatology Department, Stomatology Clinic, Hospital de Clinicas Jose de San Martin, Buenos Aires, Argentina.


Angina bullosa hemorrhagica is a rare and benign disorder, usually localized in the subepithelial layer of the oral, pharyngeal and esophageal mucosa. The lesions are characterized by their sudden onset. They appear as a painless, tense, dark red and blood-filled blister in the mouth that rapidly expand and rupture spontaneously in 24-48 hours. The underlying etiopathology remains ill defined, although it may be a multifactorial phenomenon including diabetes, and steroid inhalers. The condition is not attributable to blood dyscrasias, nor other vesicular-bullous disorders. In this study, eleven patients with such blisters are described. Physical examination of the patients revealed a single blister with hemorrhagic content localized in the oral mucosa. Biopsy of the lesions showed sub epithelial blisters with a mild infiltrate. In general practice, dermatologists could face a blood-filled bullous lesion of the oral mucosa. Recognition is, therefore, of great importance for dermatologists.



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Case Reports
angina bullosa haemorrhagica, bullous hemorrhagica, oral mucosa blisters
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How to Cite
Ruiz Beguerie, J., & Gonzalez, S. (2014). Angina bullosa hemorrhagica: report of 11 cases. Dermatology Reports, 6(1).