Ibrutinib-associated skin toxicity: a case of maculopapular rash in a 79-year old Caucasian male patient with relapsed Waldenstrom’s macroglobulinemia and review of the literature

  • Anders Bisgaard Jensen | ajensen@biomed.au.dk Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.
  • Birgitte Stausbøl-Grøn Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.
  • Rikke Riber-Hansen Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.
  • Francesco d’Amore Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.

Abstract

Waldenstrom's macroglobulinamia (WM) is a rare malignant lymphoproliferative disorder, characterized by monoclonal IgM paraproteinemia and neoplastic proliferation of malignant lymphoplasmacytoid cells in the bone marrow. Traditionally, WM has been treated with modalities similar to those used in the management of other indolent lymphomas. Just recently, based on impressive clinical trial results in heavily pretreated WM patients, a new Bruton Tyrosine Kinase-inhibitor, Ibrutinib, has been approved for the treatment of this disorder. As the use of Ibrutinib in WM outside clinical trials is still limited, only few clinical reports illustrating treatment side effects are currently available. Here we review the current literature specific on Ibrutinib-associated rash in hematologic patients, and report on an elderly patient with WM, who developed a red maculopapular non-pruritic rash 12 weeks after starting Ibrutinib therapy. Without modifications of the ongoing Ibrutinib schedule, the rash regressed within two weeks of treatment with topical steroidcontaining dermatological compounds.

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Author Biography

Anders Bisgaard Jensen, Department of Hematology, Aarhus University Hospital, Aarhus
Pregraduate researcher, dept. of Hematology, Aarhus University, Denmark
Published
2017-04-20
Section
Case Reports
Keywords:
Waldenstrom's macroglobulinamia, ibrutinib, rash, adverse effects, minireview.
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How to Cite
Jensen, A., Stausbøl-Grøn, B., Riber-Hansen, R., & d’Amore, F. (2017). Ibrutinib-associated skin toxicity: a case of maculopapular rash in a 79-year old Caucasian male patient with relapsed Waldenstrom’s macroglobulinemia and review of the literature. Dermatology Reports, 9(1). https://doi.org/10.4081/dr.2017.6976