Skin tissue expression and serum level of thymic stromal lymphopoietin in patients with psoriasis vulgaris


Submitted: 1 February 2019
Accepted: 13 May 2019
Published: 20 June 2019
Abstract Views: 1127
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Authors

  • Oki Suwarsa Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Hartati Purbo Dharmadji Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Endang Sutedja Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Lengga Herlina Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Putri Reno Sori Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Reti Hindritiani Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Reiva Farah Dwiyana Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Hendra Gunawan Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.

Thymic stromal lymphopoietin (TSLP) is known to be associated with allergic diseases. It is also suggested that TSLP has a role in autoimmune diseases such as psoriasis; however, the associated pathways remain unknown. There is currently little information on TSLP in psoriasis vulgaris. We investigated TSLP expressions on lesional and non-lesional skin of psoriasis vulgaris patients using reverse transcription- polymerase chain reaction. TSLP level was also investigated in serum from psoriasis vulgaris patients compared to healthy control using enzyme-linked immunosorbent assay. TSLP expression was higher in lesional skin (1.90) compared to non-lesional skin (1.76); however, the difference was not statistically significant (P>0.05). TSLP serum levels were significantly higher in psoriasis patients (287.40 pg/dL) as compared to controls (114.70 pg/dL) (P<0.05). This study concluded that TSLP levels in the serum of psoriasis vulgaris patients are higher than controls. TSLP was also found in keratinocyte of psoriasis patients, the expression was higher in the lesional compared to non-lesional skin; however, this difference is statistically insignificant. These findings suggest that TSLP may play a role in the pathogenesis of psoriasis vulgaris, but its exact role remains unclear.


Supporting Agencies

Universitas Padjadjaran, Bandung, West Java, Indonesia (Grant No. 2476/UN6C/LT/2018)

Suwarsa, O., Dharmadji, H. P., Sutedja, E., Herlina, L., Sori, P. R., Hindritiani, R., Dwiyana, R. F., & Gunawan, H. (2019). Skin tissue expression and serum level of thymic stromal lymphopoietin in patients with psoriasis vulgaris. Dermatology Reports, 11(1). https://doi.org/10.4081/dr.2019.8006

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