Skin tissue expression and serum level of thymic stromal lymphopoietin in patients with psoriasis vulgaris

  • Oki Suwarsa | oki.suwarsa@unpad.ac.id Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Hartati Purbo Dharmadji Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Endang Sutedja Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Lengga Herlina Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Putri Reno Sori Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Reti Hindritiani Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Reiva Farah Dwiyana Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
  • Hendra Gunawan Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran; Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.

Abstract

Thymic stromal lymphopoietin (TSLP) is known to be associated with allergic diseases. It is also suggested that TSLP has a role in autoimmune diseases such as psoriasis; however, the associated pathways remain unknown. There is currently little information on TSLP in psoriasis vulgaris. We investigated TSLP expressions on lesional and non-lesional skin of psoriasis vulgaris patients using reverse transcription- polymerase chain reaction. TSLP level was also investigated in serum from psoriasis vulgaris patients compared to healthy control using enzyme-linked immunosorbent assay. TSLP expression was higher in lesional skin (1.90) compared to non-lesional skin (1.76); however, the difference was not statistically significant (P>0.05). TSLP serum levels were significantly higher in psoriasis patients (287.40 pg/dL) as compared to controls (114.70 pg/dL) (P<0.05). This study concluded that TSLP levels in the serum of psoriasis vulgaris patients are higher than controls. TSLP was also found in keratinocyte of psoriasis patients, the expression was higher in the lesional compared to non-lesional skin; however, this difference is statistically insignificant. These findings suggest that TSLP may play a role in the pathogenesis of psoriasis vulgaris, but its exact role remains unclear.

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Published
2019-06-20
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Keywords:
Psoriasis vulgaris, Serum, Skin, Thymic stromal lymphopoietin
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How to Cite
Suwarsa, O., Dharmadji, H. P., Sutedja, E., Herlina, L., Sori, P. R., Hindritiani, R., Dwiyana, R. F., & Gunawan, H. (2019). Skin tissue expression and serum level of thymic stromal lymphopoietin in patients with psoriasis vulgaris. Dermatology Reports, 11(1). https://doi.org/10.4081/dr.2019.8006