Pyoderma gangrenosum-like necrotizing panniculitis associated with Imatinib: A case report

  • Jorge Hernández Parada Department of Pharmacy, Reina Sofía University Hospital; Instituto Maimonides de Investigacion Biomedica de Cordoba - IMIBIC, Reina Sofía University Hospital, University of Cordoba, Córdoba, Spain.
  • Alicia Sanz Department of Pathology, Reina Sofía University Hospital, Córdoba, Spain.
  • Beatriz Isla-Tejera Department of Pharmacy, Reina Sofía University Hospital; Instituto Maimonides de Investigacion Biomedica de Cordoba - IMIBIC, Reina Sofía University Hospital, University of Cordoba, Córdoba, Spain.
  • Juan Ruano | juanruanoruiz@mac.com Instituto Maimonides de Investigacion Biomedica de Cordoba - IMIBIC, Reina Sofía University Hospital, University of Cordoba; Department of Dermatology, Reina Sofía University Hospital, Córdoba Córdoba, Spain.

Abstract

Imatinib mesylate is a small tyrosine kinase inhibitor that targets BCR-ABL, ckit and platelet-derived growth factor receptor. It is prescribed by hematologists for chronic myeloid leukemia and acute lymphoblastic leukemia and by oncologists for Gastrointestinal Stromal Tumors (GIST). Cutaneous reactions to Imatinib are common but their incidence and severity widely varies between patients. A self-limited skin rash is the most common adverse effect but there have been reported cases of patients with maculopapular rash, pigmentary changes, superficial edema and rarer and clinically distinctive features such as lichenoid reactions or psoriasis. We here describe for the first time a case of pyoderma gangrenosum–like necrotizing panniculitis, a rare dermatological condition, after initiating therapy with Imatinib.

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References

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Published
2020-07-08
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Case Reports
Keywords:
Imatinib, pyoderma gangrenosum- like, necrotizing panniculitis
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How to Cite
Parada, J. H., Sanz, A., Isla-Tejera, B., & Ruano, J. (2020). Pyoderma gangrenosum-like necrotizing panniculitis associated with Imatinib: A case report. Dermatology Reports, 12(1). https://doi.org/10.4081/dr.2020.8381