Leser-Trélat sign as a rare manifestation of cutaneous melanoma

  • Niccolò Gori Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Dermatologia, Rome; Università Cattolica del Sacro Cuore, Dermatologia, Rome, Italy. https://orcid.org/0000-0003-1987-0623
  • Ilaria Esposito Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Dermatologia, Rome; Università Cattolica del Sacro Cuore, Dermatologia, Rome, Italy.
  • Laura Del Regno Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Dermatologia, Rome; Università Cattolica del Sacro Cuore, Dermatologia, Rome, Italy.
  • Alessandra D'Amore Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Dermatologia, Rome; Università Cattolica del Sacro Cuore, Dermatologia, Rome, Italy.
  • Ketty Peris Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Dermatologia, Rome; Università Cattolica del Sacro Cuore, Dermatologia, Rome, Italy.
  • Alessandro Di Stefani | alessandro.distefani@gmail.com Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Dermatologia, Rome; Università Cattolica del Sacro Cuore, Dermatologia, Rome, Italy. http://orcid.org/0000-0001-8283-2633

Abstract

Leser-Trélat Sign (LTS) is a rare paraneoplastic syndrome characterized by the sudden eruption of multiple seborrheic keratoses in patients with internal malignancy, commonly localized in the gastrointestinal tract. We report an 80-year-old female patient showing a rapid increase in the number and size of seborrheic keratosis associated with the diagnosis of a cutaneous nodular melanoma (Breslow thickness: 4.5 mm) located on the right flank. After the excision of melanoma, subsequent staging procedures resulted negative, moreover no evidence of melanoma recurrence and no changes of the seborrheic keratoses was detected after a follow-up of 52 months. Although the association between melanoma and Leser Trelat sign is rare, an accurate skin examination with the aid of dermatoscopy searching for undiagnosed skin cancers, should be suggested in patient with sudden eruption of keratosis seborrheic to early diagnose and treat a possible melanoma.

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References

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Published
2020-07-06
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Case Reports
Keywords:
Leser-Trélat sign, melanoma, oncologic patient, seborrheic keratosis., paraneoplastic syndrome
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How to Cite
Gori, N., Esposito, I., Del Regno, L., D’Amore, A., Peris, K., & Di Stefani, A. (2020). Leser-Trélat sign as a rare manifestation of cutaneous melanoma. Dermatology Reports, 12(1). https://doi.org/10.4081/dr.2020.8665