Inflammatory seborrheic keratosis resolution after hyperbaric oxygen therapy: Case presentation and pathophysiology review

  • Karin Elman-Shina | Sagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical Center, Zerifin, Israel.
  • Monica Elman Elman Dermatology and Laser Clinics, Tel Aviv, Israel.
  • Shai Efrati Sagol Center for Hyperbaric Medicine and Research, Shamir (Assaf Harofeh) Medical Center, Zerifin; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv; Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.


Seborrheic keratosis (SK) is a common epidermal tumor, consisting of a benign proliferation of immature keratinocytes. The natural history of SK is a slow progression over time and complete remission is not expected. The article presents the first case of a complete resolution of a large (2.5 cm diameter) SK lesion after hyperbaric oxygen therapy (HBOT). In addition to the case presentation, the pathophysiology of SK and the potential beneficial physiological effects of HBOT are reviewed and discussed.



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Case Reports
inflammatory, seborrheic keratosis, SK, hyperbaric
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How to Cite
Elman-Shina, K., Elman, M., & Efrati, S. (2021). Inflammatory seborrheic keratosis resolution after hyperbaric oxygen therapy: Case presentation and pathophysiology review. Dermatology Reports, 13(1).