Transformation of a myelodysplastic syndrome to acute myeloid leukemia and concurrent necrotizing Sweet' syndrome
The Sweet’ syndrome, is an inflammatory skin disorder characterized by extensive infiltration of neutrophils in the dermis with extension to the subcutis, known as acute febrile neutrophilic dermatosis. It may occur as a paraneoplastic syndrome. To our knowledge, there are currently few reports about transformation of a myelodysplastic syndrome to acute myeloid leukemia and concurrent necrotizing Sweet syndrome in the literature. Herein we describe an unusual case in a young patient with these characteristics that evolved to a fatal outcome.
Villarreal CD, Ocampo J, Villarreal A. Sweet Syndrome: A review and update. Actas Dermosifiliogr, 2016; 107 (5): 369-378. DOI: https://doi.org/10.1016/j.ad.2015.12.001
Zheng S, Li S, Tang S, Pan Y, Ding Y, Qiao J, et al. Insights into the characteristics of Sweet Syndrome in patients with and without hematologic malignancy. Front Med, 2020; 7 (20): 1-5. DOI: https://doi.org/10.3389/fmed.2020.00020
Dan H, Yanmei L, Yue X, Xian J. Sweet syndrome associated with malignancies: A retrospective analysis of 25 patients from West China hospital. Dermatol Ther, 2020; (1): 1-14. DOI: https://doi.org/10.1111/dth.13588
Gomes D, Campos G, Macchione J, Costa G. Paraneoplastic Sweet’s syndrome. An Bras Dermatol, 2018; 93 (4): 576-578. DOI: https://doi.org/10.1590/abd1806-4841.20187353
Clark AK, Sarcon AK, Fung MA, Konia T, Laurin EG, Sivamani RK. Malignancy-associated Sweet syndrome: acute febrile neutrophilic dermatosis associated with recurrence of metastatic cervical cancer. Dermatol Online J, 2017; 23 (4): 1-5.
Cohen PR, Kurzrock R. Sweet’s syndrome and malignancy. Am J Med, 1987; 82 (6): 1220-1226. DOI: https://doi.org/10.1016/0002-9343(87)90229-4
Chen SH, Kuo YT, Liu YL, Chen BJ, Lu YC, Miser JS. Acute myeloid leukemia presenting with Sweet syndrome: A case report and review of the literature. Pediatr Neonatol, 2016; 58 (3): 283-284. DOI: https://doi.org/10.1016/j.pedneo.2016.05.002
Pourmoussa A, Kwan K. An unlikely rapid transformation of myelodysplastic syndrome to acute leukemia: A case report. Perm J, 2017; 21:16-091. DOI: https://doi.org/10.7812/TPP/16-091
Djien V, Wallach D. Sweet‘s syndrome: practical conduct. Ann Dermatol Venereol, 1999; 126 (4): 343-7.
Demichelis R, Zapata N, Leyto F, Terreros E, Carrillo A, Montaño E, et al. Acute myeloid leukemia in Mexico: the specific challenges of a developing country. Results from a multicenter national registry. Clin Lymphoma Myeloma Leuk, 2019; 20(6): e295-w303. DOI: https://doi.org/10.1016/j.clml.2019.12.015
Mo W, Wang X, Wang Y, Li Y, Zhang R. Clonal neutrophil infiltrates in concurrent Sweet’s syndrome and acute myeloid leukemia: A case report and literature review. Cancer Genet, 2018; 226: 11-16. DOI: https://doi.org/10.1016/j.cancergen.2018.04.120
Lipof JS, Beck LA, Reddy SC, Southgate RD, Carney-Young K, Hammert WC. Necrotizing Sweet Syndrome of the Upper Extremity After Elective Hand Surgery. J Hand Surg Am, 2018; 43 (4): 389.e1-389.e6. DOI: https://doi.org/10.1016/j.jhsa.2017.08.019
Minamiyama R, Asai J, Kaneko Y, Kanehisa F, Cho Z, Takenaka H, et al. Necrotizing Sweet syndrome in a patient with myelodysplastic syndrome. Clin Exp Dermatol, 2017; 42(4): 436-438. DOI: https://doi.org/10.1111/ced.13088
Rochet NM, Chavan RN, Cappel MA, Wada DA, Gibson LE. Sweet syndrome: clinical presentation, associations, and response to treatment in 77 patients. J Am Acad Dermatol. 2013; 69(4):557-64. DOI: https://doi.org/10.1016/j.jaad.2013.06.023
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