Transformation of a myelodysplastic syndrome to acute myeloid leukemia and concurrent necrotizing Sweet' syndrome

  • Olga Vera-Lastra Internal Medicine Department, Hospital de Especialidades Centro Médico Nacional La Raza, IMSS, Mexico City; Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Arturo Olvera-Acevedo Internal Medicine Department, Hospital de Especialidades Centro Médico Nacional La Raza, IMSS, Mexico City; Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Nancy Pulido-Díaz Dermatology Department, Hospital de Especialidades Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Marissa de Jesús Quintal-Ramírez 4Pathology Department, Hospital de Especialidades Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Irvin Ordoñez-González Universidad Veracruzana, Veracruz, Mexico. https://orcid.org/0000-0001-7293-7132
  • Erik Cimé-Aké Internal Medicine Department, Hospital de Especialidades Centro Médico Nacional La Raza, IMSS, Mexico City; Universidad Nacional Autónoma de México, Mexico City, Mexico. https://orcid.org/0000-0002-7012-8419
  • María Pilar Cruz-Domínguez Universidad Nacional Autónoma de México, Mexico City; Translational Research Unit, Hospital de Especialidades Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Gabriela Medina | dragabymedina@yahoo.com.mx Universidad Nacional Autónoma de México, Mexico City; Research Division, Hospital de Especialidades Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico. https://orcid.org/0000-0002-5891-8653

Abstract

The Sweet’ syndrome, is an inflammatory skin disorder characterized by extensive infiltration of neutrophils in the dermis with extension to the subcutis, known as acute febrile neutrophilic dermatosis. It may occur as a paraneoplastic syndrome. To our knowledge, there are currently few reports about transformation of a myelodysplastic syndrome to acute myeloid leukemia and concurrent necrotizing Sweet syndrome in the literature. Herein we describe an unusual case in a young patient with these characteristics that evolved to a fatal outcome.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

References

Villarreal CD, Ocampo J, Villarreal A. Sweet Syndrome: A review and update. Actas Dermosifiliogr, 2016; 107 (5): 369-378. DOI: https://doi.org/10.1016/j.ad.2015.12.001

Zheng S, Li S, Tang S, Pan Y, Ding Y, Qiao J, et al. Insights into the characteristics of Sweet Syndrome in patients with and without hematologic malignancy. Front Med, 2020; 7 (20): 1-5. DOI: https://doi.org/10.3389/fmed.2020.00020

Dan H, Yanmei L, Yue X, Xian J. Sweet syndrome associated with malignancies: A retrospective analysis of 25 patients from West China hospital. Dermatol Ther, 2020; (1): 1-14. DOI: https://doi.org/10.1111/dth.13588

Gomes D, Campos G, Macchione J, Costa G. Paraneoplastic Sweet’s syndrome. An Bras Dermatol, 2018; 93 (4): 576-578. DOI: https://doi.org/10.1590/abd1806-4841.20187353

Clark AK, Sarcon AK, Fung MA, Konia T, Laurin EG, Sivamani RK. Malignancy-associated Sweet syndrome: acute febrile neutrophilic dermatosis associated with recurrence of metastatic cervical cancer. Dermatol Online J, 2017; 23 (4): 1-5.

Cohen PR, Kurzrock R. Sweet’s syndrome and malignancy. Am J Med, 1987; 82 (6): 1220-1226. DOI: https://doi.org/10.1016/0002-9343(87)90229-4

Chen SH, Kuo YT, Liu YL, Chen BJ, Lu YC, Miser JS. Acute myeloid leukemia presenting with Sweet syndrome: A case report and review of the literature. Pediatr Neonatol, 2016; 58 (3): 283-284. DOI: https://doi.org/10.1016/j.pedneo.2016.05.002

Pourmoussa A, Kwan K. An unlikely rapid transformation of myelodysplastic syndrome to acute leukemia: A case report. Perm J, 2017; 21:16-091. DOI: https://doi.org/10.7812/TPP/16-091

Djien V, Wallach D. Sweet‘s syndrome: practical conduct. Ann Dermatol Venereol, 1999; 126 (4): 343-7.

Demichelis R, Zapata N, Leyto F, Terreros E, Carrillo A, Montaño E, et al. Acute myeloid leukemia in Mexico: the specific challenges of a developing country. Results from a multicenter national registry. Clin Lymphoma Myeloma Leuk, 2019; 20(6): e295-w303. DOI: https://doi.org/10.1016/j.clml.2019.12.015

Mo W, Wang X, Wang Y, Li Y, Zhang R. Clonal neutrophil infiltrates in concurrent Sweet’s syndrome and acute myeloid leukemia: A case report and literature review. Cancer Genet, 2018; 226: 11-16. DOI: https://doi.org/10.1016/j.cancergen.2018.04.120

Lipof JS, Beck LA, Reddy SC, Southgate RD, Carney-Young K, Hammert WC. Necrotizing Sweet Syndrome of the Upper Extremity After Elective Hand Surgery. J Hand Surg Am, 2018; 43 (4): 389.e1-389.e6. DOI: https://doi.org/10.1016/j.jhsa.2017.08.019

Minamiyama R, Asai J, Kaneko Y, Kanehisa F, Cho Z, Takenaka H, et al. Necrotizing Sweet syndrome in a patient with myelodysplastic syndrome. Clin Exp Dermatol, 2017; 42(4): 436-438. DOI: https://doi.org/10.1111/ced.13088

Rochet NM, Chavan RN, Cappel MA, Wada DA, Gibson LE. Sweet syndrome: clinical presentation, associations, and response to treatment in 77 patients. J Am Acad Dermatol. 2013; 69(4):557-64. DOI: https://doi.org/10.1016/j.jaad.2013.06.023

Published
2021-03-17
Info
Issue
Section
Case Reports
Keywords:
Necrotizing Sweet syndrome, Myelodysplastic syndrome, Acute myeloid leukemia
Statistics
  • Abstract views: 2822

  • PDF: 172
  • HTML: 0
How to Cite
Vera-Lastra, O., Olvera-Acevedo, A., Pulido-Díaz, N., Quintal-Ramírez, M. de J., Ordoñez-González, I., Cimé-Aké, E., Cruz-Domínguez, M. P., & Medina, G. (2021). Transformation of a myelodysplastic syndrome to acute myeloid leukemia and concurrent necrotizing Sweet’ syndrome. Dermatology Reports, 13(1). https://doi.org/10.4081/dr.2021.9017