Dermatology Reports <p><strong>Dermatology Reports</strong> is an online-only, international, Open Access peer-reviewed journal which publish scientific papers about skin diseases. Manuscripts dealing with research, biology,&nbsp;epidemiology,&nbsp;clinics of all skin-related diseases are welcome.&nbsp;<strong>Dermatology Reports</strong> publishes original&nbsp;articles, reviews, brief reports and case reports.</p> PAGEPress Scientific Publications, Pavia, Italy en-US Dermatology Reports 2036-7392 <p><strong>PAGEPress</strong> has chosen to apply the&nbsp;<a href="" target="_blank" rel="noopener"><strong>Creative Commons Attribution NonCommercial 4.0 International License</strong></a>&nbsp;(CC BY-NC 4.0) to all manuscripts to be published.<br><br> An Open Access Publication is one that meets the following two conditions:</p> <ol> <li>the author(s) and copyright holder(s) grant(s) to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship, as well as the right to make small numbers of printed copies for their personal use.</li> <li>a complete version of the work and all supplemental materials, including a copy of the permission as stated above, in a suitable standard electronic format is deposited immediately upon initial publication in at least one online repository that is supported by an academic institution, scholarly society, government agency, or other well-established organization that seeks to enable open access, unrestricted distribution, interoperability, and long-term archiving.</li> </ol> <p>Authors who publish with this journal agree to the following terms:</p> <ol> <li>Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.</li> <li>Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.</li> <li>Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.</li> </ol> Trps1-deficient transplanted skin gave rise to a substantial amount of hair: Trps1 is unnecessary for hair development <p>Trps1 is considered as an important gene involved in the interactions between the epithelial and mesenchymal cells during hair follicle morphogenesis. The number of hair follicles in Trps1 Knockout (KO) newborn mouse skin was significantly lower than that in wild-type (WT) newborn skin. To gain insight into the functional role of Trps1 in hair development, we transplanted Trps1 KO newborn mouse skin on the backs of nude mice and examined hair growth at day 42 after transplantation. Surprisingly, transplanted skin from Trps1 KO newborn mice gave rise to a substantial amount of hair, although the hair was softer than that of WT mice. Histological examination revealed that the diameter of both hair follicles and hair shafts were significantly lower, whereas the density of hair follicles showed no significant difference between the Trps1 KO and WT mice. We introduce mouse hair follicles as a fascinating model to study the functions of Trps1 in mouse hair growth and pathology. This model suggests that the function of Trps1 is unnecessary for the development of normal hair follicles and hair shafts, although the loss of Trps1 affects the diameters of hair follicles and hair shaft.</p> Yingzhe Zhang Tomoyuki Nakamura Fukumi Furukawa Yasuteru Muragaki ##submission.copyrightStatement## 2019-01-23 2019-01-23 11 1 10.4081/dr.2019.7853 Clinical picture, diagnosis and treatment of rosacea, complicated by Demodex mites <p>The article analyzes the clinical picture and course of rosacea in patients with <em>Demodex</em> mites. It presents the advantages of using the method of confocal laser scanning microscopy over the method of light microscopy of facial skin scrapes. The aimes were to study the influence of <em>Demodex</em> mites on the clinical picture and course of rosacea; to compare laboratory and instrumental diagnostic methods for detecting <em>Demodex</em> mites; to evaluate the effectiveness of external therapy aimed at eliminating <em>Demodex</em> mites. 212 people were examined. The study included healthy patients, patients with a diagnosis of rosacea with the presence and absence of Demodex. The presence of <em>Demodex</em> mites was confirmed by two methods of study (light microscopy of skin scrapes and confocal laser scanning <em>in vivo</em> microscopy). <em>Demodex</em> mites promote the development of acute-inflammatory morphological elements, increase the duration of the condition (more than 5 years, P&lt;0.01) and the probability of recurrence (from 1 to 3 relapses in 39.5% of patients, P&lt;0.05), resulting in a decrease in the quality of life of patients (dermatology life quality index is 12.5±4.5, P&lt;0.05). Antiparasitic drug ivermectin, in the form of an external form, at a concentration of 1% has a high therapeutic efficacy (in 93.3% of cases). <em>Demodex</em> folliculorum shows signs of parasitism, while <em>Demodex</em> folliculorum brevis is a saprophyte. The severity of the condition does not depend on the quantitative load of the mites in the scrape. As an antiparasitic drug, it is recommended to use 1% ivertmectin.</p> Alexey Kubanov Yuliya Gallyamova Anzhela Kravchenko ##submission.copyrightStatement## 2019-03-28 2019-03-28 11 1 10.4081/dr.2019.7675 Dermoscopy is a new diagnostic tool in diagnosis of common hypopigmented macular disease: A descriptive study <p>One of the most frequent complaints in dermatology clinics is the eruption of hypopigmented patchy skin lesions. The aim of the study was to investigate the utility of dermoscopy in common hypopigmented macular diseases. Patients with the followings diseases were examined by dermoscopy: vitiligo, pityriasis alba, nevus depigmentosus, achromic pityriasis versicolor, idiopathic guttate hypomelanosis, and extragenital guttate lichen sclerosus. This study showed that these hypopigmented macular diseases might display specific dermoscopic features. In vitiligo, the mean dermoscopic features were the presence of a diffuse white glow with perifollicular pigment, perilesional hyperpigmentation, leukotrichia and the pigmentary network. In idiopathic guttate hypomelanosis, the characteristic features were the presence of multiple, shiny, scaly macules with welland ill-defined edges borders that coalesced into polycyclic macules. For nevus depigmentosus, the mean features were hypopigmented patches with irregular border with a faint reticular network. For pityriasis alba, the fairly ill-demarcated hypopigmented macules with fine scales were the mean feature. In lichen sclerosus, there were white structureless areas, perilesional erythematous halo, follicular plugging and white chrysalis like structures. Dermoscopy of achromic pityriasis versicolor showed a fairly demarcated white area with fine scales localized in the skin creases.</p> Khitam Al-Refu ##submission.copyrightStatement## 2018-12-21 2018-12-21 11 1 10.4081/dr.2018.7916 Evaluation of the glycemic effect of methotrexate in psoriatic arthritis patients with metabolic syndrome: A pilot study <p>Methotrexate (MTX) is a systemic immunosuppressant drug used for the treatment of psoriasis and psoriatic arthritis. Previous studies demonstrated a potential association between psoriasis and diabetes mellitus, obesity, atherosclerosis, hypertension, eventuating into metabolic syndrome. This study aimed at exploring the glycemic effects of MTX in psoriatic arthritis (PsA) patients. In this prospective cross-sectional study, 27 patients with PsA were evaluated. The status of PsA and presence of accompanying metabolic syndrome was determined by standard criteria and indices. Blood indicators including HbA1c, erythrocyte sedimentation rate, fasting blood sugar, total cholesterol, high-density lipoprotein, triglycerides, and C-reactive protein were examined before and 12 weeks after MTX therapy. There were no significant changes between HbA1c levels before and after MTX therapy in both genders (men: P=0.131, women: P=0.803). In addition, HbA1c levels in PsA patients with metabolic syndrome were not different before and after treatment (P=0.250). Finally, HbA1c levels did not change in PsA patients without metabolic syndrome before and after therapy (P=0.506). MTX in PsA patients does not appear to have hyperglycaemic effects in the short-term and can be safely used in patients with metabolic syndrome and diabetes.</p> Tannaz Dehpouri Ghasem Rahmatpour Rokni Nematollah Ahangar Narenjbon Mohamad Goldust Paul S. Yamauchi Uwe Wollina Torello Lotti Leon Kircik Vito Giuseppe Di Lernia Sidharth Sonthalia Aleksandra Vojvodic Jacek Szepietowski Philippe Bahadoran Enzo Errichetti Carmen Cantisani Laura Atzori Elham Rezaee Zekayi Kutlubay Burhan Engin Steven Nisticò Giovanni Damiani Rosalynn R.Z. Conic Andy Goren Leo Čabrijan Georgi Tchernev ##submission.copyrightStatement## 2019-05-09 2019-05-09 11 1 10.4081/dr.2019.7965 Skin tissue expression and serum level of thymic stromal lymphopoietin in patients with psoriasis vulgaris <p>Thymic stromal lymphopoietin (TSLP) is known to be associated with allergic diseases. It is also suggested that TSLP has a role in autoimmune diseases such as psoriasis; however, the associated pathways remain unknown. There is currently little information on TSLP in psoriasis vulgaris. We investigated TSLP expressions on lesional and non-lesional skin of psoriasis vulgaris patients using reverse transcription- polymerase chain reaction. TSLP level was also investigated in serum from psoriasis vulgaris patients compared to healthy control using enzyme-linked immunosorbent assay. TSLP expression was higher in lesional skin (1.90) compared to non-lesional skin (1.76); however, the difference was not statistically significant (P&gt;0.05). TSLP serum levels were significantly higher in psoriasis patients (287.40 pg/dL) as compared to controls (114.70 pg/dL) (P&lt;0.05). This study concluded that TSLP levels in the serum of psoriasis vulgaris patients are higher than controls. TSLP was also found in keratinocyte of psoriasis patients, the expression was higher in the lesional compared to non-lesional skin; however, this difference is statistically insignificant. These findings suggest that TSLP may play a role in the pathogenesis of psoriasis vulgaris, but its exact role remains unclear.</p> Oki Suwarsa Hartati Purbo Dharmadji Endang Sutedja Lengga Herlina Putri Reno Sori Reti Hindritiani Reiva Farah Dwiyana Hendra Gunawan ##submission.copyrightStatement## 2019-06-20 2019-06-20 11 1 10.4081/dr.2019.8006 Seborrheic keratosis evolution into squamous cell carcinoma: A truly modified sun-related tumor? A case report and review of the literature <p>The incidence of seborrheic keratosis (SK) generally increases with age and are mostly localized on the trunk, face and neck, especially on sun-exposed areas. The association between SK and skin malignancies appears to be accidental, but <em>in situ</em> transformation occurs more frequently in sun-exposed areas. Histopathological examination of all SK cases should be considered, especially when SK lesions exhibit atypical clinical manifestations, such as ulceration and cresting, as they may herald malignant transformation. In addition, other features associated with malignant transformation include excoriations or hemorrhages identified on the lesion, modification and evolution of the macroscopic characteristics, and the presence of local erythema or pruritus. Immunocompromised patients exhibit an increased risk of malignant transformation, even when radiation is involved.</p> Ioana Cimpean Ivan Theate Olivier Vanhooteghem ##submission.copyrightStatement## 2019-04-17 2019-04-17 11 1 10.4081/dr.2019.7999