Preparation and preclinical evaluation of aceclofenac loaded pectinate mucoadhesive microspheres

  • Santanu Chakraborty | santanu_nil@rediffmail.com Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur, Orissa, India.
  • Priyanka Nayak Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur, Orissa, India.
  • Bala Murali Krishna Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur, Orissa, India.
  • Madhusmruti Khandai Department of Pharmaceutics, Royal College of Pharmacy and Health Sciences, Berhampur, Orissa, India.
  • Ashoke Kumar Ghosh School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh, India.

Abstract

The aim of the present research work was to fabricate aceclofenac loaded pectinate microspheres by ionic gelation method and evaluate the effect of different cross-linking agents and polymer concentration on particle size, encapsulation efficacy and drug release behavior. It was also investigated that whether this pectinate dosage form was able to target the drug release in intestinal region and prevent the different side effect associated with the drug in stomach or not. It was observed that particle size, encapsulation efficacy and in vitro drug release were largely depended on polymer concentration and cross-linking agents. It was also observed that pectinate microspheres showed excellent pH depended mucoadhesive properties and they were able to restrict the drug release in stomach. In vitro drug release study showed that alminium-pectinate microspheres have more sustaining property as compared to barium-pectinate microspheres. Holm-Sidak multiple comparison analysis suggested a significant difference in measured t50% values among all the formulations with same cross-linking agent. In vivo studies revealed that the anti inflammatory and analgesic effects induced by pectinate microspheres were significantly high and prolonged as compared to pure drug. So, pectinate microspheres can be an excellent carrier for targeting the delivery of aceclofenac as well as help in improving the patient compliance by prolonging the systemic absorption.

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Published
2012-03-13
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Original Articles
Keywords:
Pectinate microspheres, aceclofenac, Holm-Sidak multiple comparison analysis, preclinical studies.
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How to Cite
Chakraborty, S., Nayak, P., Krishna, B. M., Khandai, M., & Ghosh, A. K. (2012). Preparation and preclinical evaluation of aceclofenac loaded pectinate mucoadhesive microspheres. Drugs and Therapy Studies, 2(1), e8. https://doi.org/10.4081/dts.2012.e8