Prognostic and predictive roles of microRNA-383 in colorectal cancer

  • Alavieh Fateh Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Iran, Islamic Republic of.
  • Mohammad Ali Hosseinpour Feizi | pourfeizi@eastp.ir Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Iran, Islamic Republic of.
  • Reza Safaralizadeh Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Iran, Islamic Republic of.
  • Mohammad Hossein Somi Liver and Gastroenterology Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of.
  • Reyhaneh Ravanbakhsh Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Iran, Islamic Republic of.
  • Behrouz Shokoohi Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of.
  • Shahryar Hashemzadeh Department of General and Thoracic Surgery, Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of.
  • Shirin Azarbarzin Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Iran, Islamic Republic of.

Abstract

MicroRNAs (miRNAs) are impressive regulators of gene expression that have a critical role in the pathogenesis of colorectal cancer (CRC). With respect to the aberrant expression of miRNA-383 (miR-383) in some types of human malignancy, this prospective study characterized its contribution to CRC tumorigenesis. The real-time reverse transcriptionpolymerase chain reaction was used to examine miR-383 expression levels prospectively in 40 sample pairs of CRC tissues and adjacent noncancerous tissues (>2 cm from cancer tissue). No significant relationship was found between miR-383 expression levels and clinicopathological features. The ability of miR-383 to function as a tumor marker was also examined. Showing significant changes overall, miR-383 expression levels were significantly down regulated in the group of CRC samples compared with matched noncancerous tissue samples. A receiver-operating characteristic (ROC) curve also showed ROC area of 70% for miR-383 with 68 and 75% sensitivity and specificity, respectively. Therefore, miR-383 can be considered as a tumor marker in CRC and help as a potential predictive biomarker in the diagnosis of colorectal cancer.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2016-08-19
Info
Issue
Section
Articles
Keywords:
biomarker, colorectal cancer, microRNA, miR-383
Statistics
  • Abstract views: 1128

  • PDF: 437
How to Cite
Fateh, A., Hosseinpour Feizi, M. A., Safaralizadeh, R., Somi, M. H., Ravanbakhsh, R., Shokoohi, B., Hashemzadeh, S., & Azarbarzin, S. (2016). Prognostic and predictive roles of microRNA-383 in colorectal cancer. Gastroenterology Insights, 7(1). https://doi.org/10.4081/gi.2016.6641