Gemcitabine


https://doi.org/10.4081/hmr.v3i1.542
Vol. 3 No. 1: 2006...2009: Now we know T-cell lymphomas better, Bologna, Italy, 16-18 March 2009
Published: June 11, 2009
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Gemcitabine (2',2'-difluorodeoxy- cytidine, dFdC) is an analog of deoxycytidine. It is transformed to the active triphosphate (dFdCTP) after intracellular phosphorylation. Gemcitabine monophosphate is inserted into the DNA and inhibits DNA elongation as a false nucleotide. In contrast to other antimetabolites, an additional, altered nucleotide is inserted behind dFdC inhibiting repair mechanisms (masked chain termination).

Supporting Agencies


Tani, M., Alinari, L., Broccoli, A., Derenzini, E., Fina, M., Gandolfi, L., Marchi, E., Pellegrini, C., Stefoni, V., Venturini, F., & Zinzani, P. (2009). Gemcitabine. Hematology Meeting Reports (formerly Haematologica Reports), 3(1). https://doi.org/10.4081/hmr.v3i1.542
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