Innovative treatments: bexarotene


https://doi.org/10.4081/hmr.v3i1.544
Vol. 3 No. 1: 2006...2009: Now we know T-cell lymphomas better, Bologna, Italy, 16-18 March 2009
Published: June 11, 2009
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There are now three FDA approved therapies for cutaneous T-cell lymphoma (CTCL) in the United States: denileukin diftitox (Ontak®, an interleukin (IL)-2 fusion protein, approved in 1998), bexarotene (Targretin®, the first retinoid-X receptor (RXR)-selective retinoid, approved in 1999), and vorinostat (a histone deacetylase inhibitor approved in 2006). These agents were approved based on Phase II clinical trials conducted in a limited number of CTCL patients. Treatment strategies in the management of MF are aimed at removal of the persistent antigen stimulus, reversal of the shift from Th2 to Th1 cytokine expression, inducing an increase in CD8+ cells, avoidance of immunosuppression, and prophylaxis or treatment of associated infectious complications. How best to integrate the new agents with existing therapies will require additional welldesigned, randomised trials. Our goal should be to produce rational combinations of drugs that can either induce a cure or prolonged complete responses in patients.

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Duvic, M. (2009). Innovative treatments: bexarotene. Hematology Meeting Reports (formerly Haematologica Reports), 3(1). https://doi.org/10.4081/hmr.v3i1.544
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