Powered bone marrow biopsy procedures produce larger core specimens, with less pain, in less time than with standard manual devices

  • Larry J. Miller
  • Thomas E. Philbeck | thomas.philbeck@vidacare.com
  • Diana F. Montez
  • Tatiana A. Puga
  • Kim E. Brodie
  • Stephen C. Cohen
  • Cathy Spadaccini
  • Ronan Swords
  • Andrew J. Brenner

Abstract

Bone marrow sampling remains essential in the evaluation of hematopoietic and many non-hematopoietic disorders. One common limitation to these procedures is the discomfort experienced by patients. To address whether a Powered biopsy system could reduce discomfort while providing equivalent or better results, we performed a randomized trial in adult volunteers. Twenty-six subjects underwent bilateral biopsies with each device. Core samples were obtained in 66.7% of Manual insertions; 100% of Powered insertions (P=0.002). Initial mean biopsy core lengths were 11.1±4.5 mm for the Manual device; 17.0±6.8 mm for the Powered device (P<0.005). Pathology assessment for the Manual device showed a mean length of 6.1±5.6 mm, width of 1.0±0.7 mm, and volume of 11.0±10.8 mm3. Powered device measurements were mean length of 15.3±6.1 mm, width of 2.0±0.3 mm, and volume of 49.1±21.5 mm3 (P<0.001). The mean time to core ejection was 86 seconds for Manual device; 47 seconds for the Powered device (P<0.001). The mean second look overall pain score was 33.3 for the Manual device; 20.9 for the Powered (P=0.039). We conclude that the Powered biopsy device produces superior sized specimens, with less overall pain, in less time.

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Published
2011-07-18
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Original Articles
Keywords:
bone marrow biopsy, core biopsy, trephine biopsy, powered biopsy
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How to Cite
Miller, L. J., Philbeck, T. E., Montez, D. F., Puga, T. A., Brodie, K. E., Cohen, S. C., Spadaccini, C., Swords, R., & Brenner, A. J. (2011). Powered bone marrow biopsy procedures produce larger core specimens, with less pain, in less time than with standard manual devices. Hematology Reports, 3(1), e8. https://doi.org/10.4081/hr.2011.e8