Recurrent gastrointestinal hemorrhage in treatment with dasatinib in a patient showing SMAD4 mutation with acute lymphoblastic leukemia Philadelphia positive and juvenile polyposis hereditary hemorrhagic telangiectasia syndrome

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Chiara Sartor
Cristina Papayannidis
Maria Chiara Abbenante
Ilaria Iacobucci
Alessandro Broccoli
Claudia Venturi
Nicoletta Testoni
Anna Ferrari
Giovanni Martinelli *
(*) Corresponding Author:
Giovanni Martinelli | martg@tin.it

Abstract

We report a case of a patient affected by juvenile polyposis and hereditary hemorrhagic telangiectasia linked to a SMAD4 mutation who developed acute lymphoblastic leukemia positive for the Philadelphia chromosome translocation and with a complex karyotype. During the treatment with the tyrosine kinase inhibitor dasatinib the patient presented recurrent severe gastrointestinal hemorrhages linked to the genetic background and aggravated by thrombocytopenia.

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