Reduced intensity allogeneic stem cell transplant for treatment of blastic plasmacytoid dendritic cell neoplasm

  • Anand Lokare Hematology Department, University Hospital Walsgrave, Coventry, United Kingdom.
  • Emmanouil Nikolousis | emelni@hotmail.com Hematology Department, Heart of England Hospital NHS Trust, Birmingham, United Kingdom.
  • Neil Phillips Hematology Department, University Hopital North Staffordshire, Stoke on Trent, United Kingdom.
  • Zbignieuw Rudzki Histopathology Department, Heart of England NHS Trust, Birmingham, United Kingdom.
  • Richard Lovell Hematology Department, Heart of England Hospital NHS Trust, Birmingham, United Kingdom.
  • Bhuvan Kishore Hematology Department, Heart of England Hospital NHS Trust, Birmingham, United Kingdom.
  • Don Milligan Hematology Department, Heart of England Hospital NHS Trust, Birmingham, United Kingdom.
  • Shankara Paneesha Hematology Department, Heart of England Hospital NHS Trust, Birmingham, United Kingdom.

Abstract

Blastic plasmacytoid dendritic cell neoplasm is a rare, aggressive tumor characterized by skin and/or marrow infiltration by CD4+ CD56+ cells. Historically, the tumor was variably thought to arise from either monocytes, T cells or NK cells giving rise to terms such as CD4+/CD56+ acute monoblastic leukemia, primary cutaneous CD4+/CD56+ hematodermic tumor and blastic NK-cell lymphoma. Whilst considerable progress has been made in understanding the histogenesis, the best modality of treatment remains to be defined. We are therefore reporting this case which was successfully treated with a T-deplete allogeneic transplant and the patient is currently alive and in remission 4 years post transplant.

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Published
2014-01-29
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Section
Case Reports
Keywords:
blastic plasmacytoid dendritic neoplasm, reduced intensity allograft, T-deplete
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How to Cite
Lokare, A., Nikolousis, E., Phillips, N., Rudzki, Z., Lovell, R., Kishore, B., Milligan, D., & Paneesha, S. (2014). Reduced intensity allogeneic stem cell transplant for treatment of blastic plasmacytoid dendritic cell neoplasm. Hematology Reports, 6(1). https://doi.org/10.4081/hr.2014.5119