Posterior reversible encephalopathy syndrome in a B-cell acute lymphoblastic leukemia young adult patient treated with a pediatric-like chemotherapeutic schedule

  • Cristina Papayannidis | cristina.papayannidis@unibo.it Department of Experimental, Diagnostic and Specialty Medicine, Bologna University, Italy.
  • Francesca Volpato Department of Experimental, Diagnostic and Specialty Medicine, Bologna University, Italy.
  • Ilaria Iacobucci Department of Experimental, Diagnostic and Specialty Medicine, Bologna University, Italy.
  • Maria Chiara Abbenante Department of Experimental, Diagnostic and Specialty Medicine, Bologna University, Italy.
  • Chiara Sartor Department of Experimental, Diagnostic and Specialty Medicine, Bologna University, Italy.
  • Giovanni Martinelli Department of Experimental, Diagnostic and Specialty Medicine, Bologna University, Italy.

Abstract

We report here the case of a young adult affected by pre B-cell acute lymphoblastic leukemia (ALL), who developed, during a pediatric-like chemotherapy consolidation schedule with high dosage of Methotrexate, a severe neurological toxicity. Clinical presentation and neuroimaging data were diagnostic for posterior reversible encephalopathy syndrome (PRES). A complete resolution was quickly obtained with medical blood pressure control and anticonvulsants administration. To the best of our knowledge, this is the first case of PRES described in the adult ALL setting. Currently, the clinical management of this aggressive disease is moving towards a pediatric-like approach also in adult patients, due to the better outcome reached with intensive chemotherapeutic regimens in children population. However, therapy-related toxicities have to be taken into account, since their onset may adversely affect patients’ clinical outcome.

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Published
2014-09-30
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Section
Case Reports
Keywords:
posterior reversible encephalopathy syndrome, acute lymphoblastic leukemia, methotrexate, seizure, brain magnetic resonance imaging
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How to Cite
Papayannidis, C., Volpato, F., Iacobucci, I., Abbenante, M. C., Sartor, C., & Martinelli, G. (2014). Posterior reversible encephalopathy syndrome in a B-cell acute lymphoblastic leukemia young adult patient treated with a pediatric-like chemotherapeutic schedule. Hematology Reports, 6(3). https://doi.org/10.4081/hr.2014.5565