Docosahexaenoic acid induces apoptosis in primary chronic lymphocytic leukemia cells

  • Romain Guièze | rguieze@chu-clermontferrand.fr Service de Thérapie Cellulaire et d’Hématologie Clinique Adulte, Hôpital Estaing, CHU de Clermont-Ferrand; Cancer Resistance Exploring and Targeting EA 7283, Université d’Auvergne, Clermont-Ferrand, France.
  • Emmanuel Gyan Service d’Hématologie et de thérapie cellulaire, Centre Hospitalier Universitaire, CHU de Tours; Université François Rabelais, Tours, France.
  • Olivier Tournilhac Service de Thérapie Cellulaire et d’Hématologie Clinique Adulte, Hôpital Estaing, CHU de Clermont-Ferrand; Cancer Resistance Exploring and Targeting EA 7283, Université d’Auvergne, Clermont-Ferrand, France.
  • Christelle Halty Université François Rabelais, Tours, France.
  • Richard Veyrat-Masson Cancer Resistance Exploring and Targeting EA 7283, Université d’Auvergne, Clermont-Ferrand; Laboratoire d’Hématologie, Hôpital Estaing, CHU de Clermont-Ferrand, France.
  • Saïda Akil Laboratoire d’Hématologie, Hôpital Estaing, CHU de Clermont-Ferrand, France.
  • Marc Berger Cancer Resistance Exploring and Targeting EA 7283, Université d’Auvergne, Clermont-Ferrand; Laboratoire d’Hématologie, Hôpital Estaing, CHU de Clermont-Ferrand, France.
  • Olivier Hérault Université François Rabelais, Tours, France.
  • Mary Callanan Joseph Fourier University, Grenoble; INSERM, U823, Institut Albert Bonniot, Grenoble; Onco-Hematology Genetics Unit, Plateforme hospitalière de génétique moléculaire des tumeurs, Pôle de biologie, CHU-Grenoble, France.
  • Jacques-Olivier Bay Service de Thérapie Cellulaire et d’Hématologie Clinique Adulte, Hôpital Estaing, CHU de Clermont-Ferrand; Cancer Resistance Exploring and Targeting EA 7283, Université d’Auvergne, Clermont-Ferrand, France.

Abstract

Chronic lymphocytic leukemia is an indolent disorder with an increased infectious risk remaining one of the main causes of death. Development of therapies with higher safety profile is thus a challenging issue. Docosahexaenoic acid (DHA, 22:6) is an omega-3 fatty acid, a natural compound of normal cells, and has been shown to display antitumor potency in cancer. We evaluated the potential in vitro effect of DHA in primary CLL cells. DHA induces high level of in vitro apoptosis compared to oleic acid in a dose-dependent and time-dependent manner. Estimation of IC50 was only of 4.813 μM, which appears lower than those reported in solid cancers. DHA is highly active on CLL cells in vitro. This observation provides a rationale for further studies aiming to understand its mechanisms of action and its potent in vivo activity.

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Published
2015-12-17
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Brief Reports
Keywords:
Chronic lymphocytic leukemia, docosahexaenoic acid
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How to Cite
Guièze, R., Gyan, E., Tournilhac, O., Halty, C., Veyrat-Masson, R., Akil, S., Berger, M., Hérault, O., Callanan, M., & Bay, J.-O. (2015). Docosahexaenoic acid induces apoptosis in primary chronic lymphocytic leukemia cells. Hematology Reports, 7(4). https://doi.org/10.4081/hr.2015.6043