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Extranodal diffuse large B-cell lymphomas: A retrospective case series and review of the literature

Stergios Boussios, Ioannis Zerdes, Amalia Vassou, Eleni Bareta, Esmeralda Seraj, Alexandra Papoudou-Bai, Nicholas Pavlidis, Anna Batistatou, George Pentheroudakis
  • Stergios Boussios
    Department of Medical Oncology, University of Ioannina; Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Greece
  • Ioannis Zerdes
    Department of Medical Oncology, University of Ioannina; Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Greece
  • Amalia Vassou
    Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN); Department of Hematology, University of Ioannina, Greece
  • Eleni Bareta
    Department of Medical Oncology, University of Ioannina; Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Greece
  • Esmeralda Seraj
    Department of Medical Oncology, University of Ioannina; Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Greece
  • Alexandra Papoudou-Bai
    Department of Pathology, Medical School, University of Ioannina, Greece
  • Nicholas Pavlidis
    Department of Medical Oncology, University of Ioannina; Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Greece
  • Anna Batistatou
    Department of Pathology, Medical School, University of Ioannina, Greece
  • George Pentheroudakis
    Department of Medical Oncology, University of Ioannina; Society for Study of Clonal Heterogeneity of Neoplasia (EMEKEN), Greece | gpenther@otenet.gr

Abstract

Non-Hodgkin lymphomas commonly show extranodal involvement (25-30%) but primary diffuse large B-cell lymphomas(DLBCL) with extranodal localization represent clinically and molecularly distinct entities. The present study involved retrospective analysis of case records of 4 patients who were diagnosed with extranodal DLBCL between 2010 and 2016 at the Medical Oncology and Hematology Departments of the Ioannina University Hospital, Greece. Median age of presentation was 69 years (range 60-77 years). There were 2 males and 2 females. The sites of DLBCL involvement included adrenal gland, mandible, cervix uteri, and ileum. Two patients had B symptoms while none had bone marrow involvement. After staging workup, all the patients fell into IE stage. The treatment approach included chemotherapy combined with rituximab (R), whereas one patient received additionally irradiation therapy. Post-treatment positron emission tomography-computed tomography scan was performed in 3 patients. In terms of the outcome, 3 patients are alive in complete response, whereas one was lost in follow-up. Further prospective data analyses are required so as to better elucidate the biology and course of extranodal DLBCL.

Keywords

Chemotherapy; Extranodal; Lymphomas; Immunohistochemistry

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Submitted: 2017-01-28 20:08:36
Published: 2018-04-03 08:48:42
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Copyright (c) 2018 Stergios Boussios

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