Long-term complete remission of early hematological relapse after discontinuation of immunosuppressants following allogeneic transplantation for Sezary syndrome

  • Hiroki Hosoi Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
  • Kazuo Hatanaka Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
  • Shogo Murata Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
  • Toshiki Mushino Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
  • Kodai Kuriyama Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
  • Akinori Nishikawa Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
  • Nobuyoshi Hanaoka Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
  • Shinobu Tamura Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
  • Hideki Nakakuma Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
  • Takashi Sonoki | sonoki@wakayama-med.ac.jp Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.

Abstract

Sezary syndrome (SS) is a leukemic form of cutaneous T-cell lymphoma and is chemo-resistant. Allogeneic hematopoietic stem cell transplantation is a promising therapy for SS; however, relapse is common. Therapeutic options after relapse have not been established. We managed an SS patient with hematological relapse within one month after transplantation. After discontinuation of immunosuppressants, she achieved complete remission and remained relapse-free. The chimeric analyses of Tcells showed that the full recipient type became complete donor chimera after immunological symptoms. This clinical course suggested that discontinuation of immunosuppressants may result in a graftversus- tumor effect, leading to the eradication of lymphoma cells.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2018-09-05
Info
Issue
Section
Case Reports
Keywords:
Sezary syndrome, Allo-HSCT, Graft versus tumor effect
Statistics
  • Abstract views: 579

  • PDF: 306
  • HTML: 36
How to Cite
Hosoi, H., Hatanaka, K., Murata, S., Mushino, T., Kuriyama, K., Nishikawa, A., Hanaoka, N., Tamura, S., Nakakuma, H., & Sonoki, T. (2018). Long-term complete remission of early hematological relapse after discontinuation of immunosuppressants following allogeneic transplantation for Sezary syndrome. Hematology Reports, 10(3). https://doi.org/10.4081/hr.2018.7497

Most read articles by the same author(s)