Myelodysplasia-related acute myeloid leukemia and acute promyelocytic leukemia: concomitant occurrence of two molecularly distinct diseases

  • Yenny Alejandra Moreno Vanegas Divisions of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, United States.
  • Abdel-Ghani M. Azzouqa Divisions of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, United States.
  • David M. Menke Department of Laboratory Medicine and Pathology, Medical Oncology, Mayo Clinic, Jacksonville, FL, United States.
  • James M. Foran Divisions of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, United States.
  • Prakash Vishnu | vishnu.prakash@mayo.edu Divisions of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, United States.

Abstract

Concurrent presentation of acute promyelocytic leukemia (APL) with other hematologic diseases in the absence of previous chemotherapy or ionizing radiotherapy treatment is very rare. We present a case of simultaneous occurrence of APL with myelodysplastic syndrome (MDS)-related acute myeloid leukemia (AML). A 43-yearold female presented with 3 month of history fatigue, night sweats, chills and pancytopenia. Bone marrow aspirate and biopsy demonstrated 20% myeloid blasts with dysplastic changes admixed with abnormal promyelocytes. Cytogenetic analysis showed tetraploidy and deletion in chromosomes 5q and 7q and polymerase chain reaction showed presence of PML/RARA mRNA transcripts, confirming the presence of concurrent APL and MDS-related AML. Induction chemotherapy with cytarabine and daunorubicin was initiated along with all-trans retinoic acid. This is the first case to be reported in the literature of concurrent occurrence of APL with MDS-related AML. Treatment with 7 + 3 regimen and ATRA was successful in inducing complete remission.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2018-09-05
Info
Issue
Section
Case Reports
Keywords:
Acute myeloid leukemia, myelodysplastic syndrome, acute promyelocytic leukemia, management.
Statistics
  • Abstract views: 675

  • PDF: 296
  • HTML: 55
How to Cite
Moreno Vanegas, Y., Azzouqa, A.-G., Menke, D., Foran, J., & Vishnu, P. (2018). Myelodysplasia-related acute myeloid leukemia and acute promyelocytic leukemia: concomitant occurrence of two molecularly distinct diseases. Hematology Reports, 10(3). https://doi.org/10.4081/hr.2018.7658