Cover Image

Myelodysplasia-related acute myeloid leukemia and acute promyelocytic leukemia: concomitant occurrence of two molecularly distinct diseases

Yenny Alejandra Moreno Vanegas, Abdel-Ghani M. Azzouqa, David M. Menke, James M. Foran, Prakash Vishnu
  • Yenny Alejandra Moreno Vanegas
    Divisions of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, United States
  • Abdel-Ghani M. Azzouqa
    Divisions of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, United States
  • David M. Menke
    Department of Laboratory Medicine and Pathology, Medical Oncology, Mayo Clinic, Jacksonville, FL, United States
  • James M. Foran
    Divisions of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, United States
  • Prakash Vishnu
    Divisions of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, United States | vishnu.prakash@mayo.edu

Abstract

Concurrent presentation of acute promyelocytic leukemia (APL) with other hematologic diseases in the absence of previous chemotherapy or ionizing radiotherapy treatment is very rare. We present a case of simultaneous occurrence of APL with myelodysplastic syndrome (MDS)-related acute myeloid leukemia (AML). A 43-yearold female presented with 3 month of history fatigue, night sweats, chills and pancytopenia. Bone marrow aspirate and biopsy demonstrated 20% myeloid blasts with dysplastic changes admixed with abnormal promyelocytes. Cytogenetic analysis showed tetraploidy and deletion in chromosomes 5q and 7q and polymerase chain reaction showed presence of PML/RARA mRNA transcripts, confirming the presence of concurrent APL and MDS-related AML. Induction chemotherapy with cytarabine and daunorubicin was initiated along with all-trans retinoic acid. This is the first case to be reported in the literature of concurrent occurrence of APL with MDS-related AML. Treatment with 7 + 3 regimen and ATRA was successful in inducing complete remission.

Keywords

Acute myeloid leukemia, myelodysplastic syndrome, acute promyelocytic leukemia, management.

Full Text:

PDF
Submitted: 2018-02-26 14:36:07
Published: 2018-09-05 10:10:13
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
43

Views:
PDF
11

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2018 Yenny Alejandra Moreno Vanegas, Abdel-Ghani M Azzouqa, David M Menke, James M Foran, Prakash Vishnu

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185     •     Privacy