A unique case of durable complete remission after salvage with azacitidine and DLI for high risk flt-3 positive acute myeloid leukemia, following relapse 18 months post allogeneic stem cell transplant

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Claire Horgan
Alexandros Kanellopoulos
Shankara Paneesha
Bhuvan Kishore
Richard Lovell
Emmanouil Nikolousis *
(*) Corresponding Author:
Emmanouil Nikolousis | manos.nikolousis@heartofengland.nhs.uk

Abstract

A unique case of primary refractory FLT3-itd mutated acute myeloid leukemia in an elderly patient, who achieved completed morphological remission, and FLT3-itd negativity, following 9 cycles of azacitadine in combination with escalating doses of donor lymphocyte infusions following relapse 18 months post reduced intensity HLAA mismatch Campath conditioning allogeneic stem cell transplant.


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