Effect of antiepileptic drugs on plasma fibrinogen level

  • R. El-Ashry | Rasha_elashery@yahoo.com Faculty of Medicine, Mansoura University, Egypt.
  • M.M. El-Ayuoty Faculty of Medicine, Mansoura University, Egypt.
  • H.A. Azzam Faculty of Medicine, Mansoura University, Egypt.
  • M.A. El-Naggar Faculty of Medicine, Mansoura University, Egypt.

Abstract

Background: Childhood  epilepsy  is  one  of  the  most  common  neurological  disorders  in pediatrics . The  prevalence  of  active  epilepsy is 5–8 per 1000 population  in developed countries  and  10 per 1000  population in  developing nations . There is a significant relationship between epilepsy and cognitive deficits. Aim of study: prospective study to evaluate the effect of the most commonly used anti-epileptics drugs on plasma fibrinogen level. Patient and methods 100 newly diagnosed patients (2months to 15 years old) selected from Outpatient Clinic of Neurology attending Mansoura University Children’s Hospital for plasma fibrinogen level evaluation by taking basal sample and second sample after six months after the basal one. Results: This study showed that, significant positive correlation between plasma fibrinogen level and the use of antiepileptic drugs. Conclusion: epileptic patient should be closely monitored during Antiepileptic drugs treatment and prior to surgical procedures as they can affect plasma fibrinogen level and coagulation profile.

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Published
2020-05-07
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Advance online
Keywords:
Epilepsy, antiepileptic drugs (AED), coagulation, plasma fibrinogen
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How to Cite
El-Ashry, R., El-Ayuoty, M., Azzam, H., & El-Naggar, M. (2020). Effect of antiepileptic drugs on plasma fibrinogen level. Hematology Reports, 12(1). https://doi.org/10.4081/hr.2020.7952