Immunoistochemical expression of PD-1 and PD-L1 in bone marrow biopsies of patients with acute myeloid leukemia

  • Francesco Romano | francesco90romano@gmail.com University of Palermo, Italy.
  • Antonino Giulio Giannone University of Palermo, Italy.
  • Sergio Siragusa University of Palermo, Italy.
  • Rossana Porcasi University of Palermo, Italy.
  • Ada Maria Florena University of Palermo, Italy.

Abstract

tumor immunotherapy is a rapidly evolving field. The discovery of the ability of neoplasms to evade the immune response has shifted the attention of the medical community to the underlying mechanisms of the immune response to tumors, highlighting the importance of so-called immune check points, including CTLA4, TIM-3 and PD-1.  an immune escape mechanism is the activation of the immune checkpoint pathway that contributes to the creation of an immunosuppressive microenvironment and therefore to tumor proliferation.although immune checkpoints have been extensively investigated in solid tumors, the same is not true for hematologic neoplasms, particularly for myeloid malignancies. our study is based on the evaluation of the activation of the PD-1 and PD-L1 pathway in the context of the bone marrow tumor microenvironment of patients with acute myeloid leukemia. To do so we evaluated  34 bone marrow biopsies of patients with acute myeloid leukemia comparing them to 10 controls using immunohistochemical methods.

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Published
2020-05-07
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Advance online
Keywords:
acute myeloid leukemia; immune check-point blockade; PD-1; PD-L1; immunotherapy
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How to Cite
Romano, F., Giannone, A. G., Siragusa, S., Porcasi, R., & Florena, A. M. (2020). Immunoistochemical expression of PD-1 and PD-L1 in bone marrow biopsies of patients with acute myeloid leukemia. Hematology Reports, 12(1). https://doi.org/10.4081/hr.2020.8211