Hemorrhagic cystitis: A successful outcome for a challenging complication in stem cell transplant

  • Sergio Pinzón Mariño | spinzon48@gmail.com Department of Hematology and Hemotherapy, Hospital Universitario Miguel Servet, Spain.
  • Samira Bakali Badesa Department of Anatomical Pathology, Hospital Universitario Miguel Servet, Spain.
  • María Jesús Viso Soriano Department of Anatomical Pathology, Hospital Universitario Miguel Servet, Spain.
  • Isabel Izquierdo Garcia Department of Hematology and Hemotherapy, Hospital Universitario Miguel Servet, Spain.

Abstract

Hemorrhagic cystitis (HC) secondary to BK polyomavirus (BKPyV) is a frequent complication related to allogenic stem cell transplantation. With an important morbidity and mortality, this disease doesn’t have a stablished standard treatment or prophylaxis strategies. At this moment, the supportive therapies approved to treat included hyperhydration, forced diuresis and transfusion support. Cidofovir is a nucleotide analog of deoxycytidine monophosphate against DNA viruses and it has been described for the treatment of BKPyV-HC, but at this moment, is not a front-line therapy. We report a successful case after the use of Cidofovir without Probenecid. No adverse effect was developed under the treatment, and after 4 weeks of treatment, the patient achieved an excellent response.

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References

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Published
2021-03-12
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Section
Case Reports
Keywords:
BK virus, Cidofovir, Hematopoietic stem cell transplantation, Virus-associated hemorrhagic cystitis
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How to Cite
Pinzón Mariño, S., Bakali Badesa, S., Viso Soriano, M. J., & Izquierdo Garcia, I. (2021). Hemorrhagic cystitis: A successful outcome for a challenging complication in stem cell transplant. Hematology Reports, 13(1). https://doi.org/10.4081/hr.2021.8574