Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome

  • Vanya Slavcheva | slavcheva@abv.bg Hematologist-University Hospital Pleven, Bulgaria.
  • T. Lukanov
  • G. Balatsenko
  • S. Angelova
  • А. Antonov
  • L. Bogdanov
  • N. Tsvetkov

Abstract

Klinefelter’s syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia- M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corre-sponding to Klinefelter’s syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically.

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Author Biography

Vanya Slavcheva, Hematologist-University Hospital Pleven
Hematology -Hematologist,MD
Published
2010-12-22
Info
Issue
Section
Case Reports
Keywords:
Genetics, Klinefelter`s syndrome, Leukemia, Remission
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How to Cite
Slavcheva, V., Lukanov, T., Balatsenko, G., Angelova, S., AntonovА., Bogdanov, L., & Tsvetkov, N. (2010). Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome. Hematology Reports, 2(1), e11. https://doi.org/10.4081/hr.2010.e11