Clinical case of acute myeloblastic leukemia with t(8;21)(q22;q22) in a patient with Klinefelter’s syndrome

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Vanya Slavcheva *
T. Lukanov
G. Balatsenko
S. Angelova
А. Antonov
L. Bogdanov
N. Tsvetkov
(*) Corresponding Author:
Vanya Slavcheva |


Klinefelter’s syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia- M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corre-sponding to Klinefelter’s syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically.

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Author Biography

Vanya Slavcheva, Hematologist-University Hospital Pleven

Hematology -Hematologist,MD